养血清脑颗粒对脑梗死后头痛、头晕的临床疗效观察

张美娇　崔利　程政平　赵华

【摘要】 目的 观察养血清脑颗粒对脑梗死后患者头痛、头晕症状的临床疗效。方法 65例脑梗死后出现头痛、头晕的患者为研究对象， 随机分成观察组（34例）和对照组（31例）， 对照组给予常规治疗， 观察组在常规治疗基础上联合养血清脑颗粒治疗。比较两组临床疗效， 治疗前后血液流变学指标[血浆粘度、全血低切粘度、花生四烯酸诱导的血小板最大聚集率（MARAA）、二磷酸腺苷诱导的血小板最大聚集率（MARADP）]水平， 治疗前后头痛评分、头晕程度， 治疗前后生活质量改善情况。结果 治疗后， 观察组总有效率为94.1%， 高于对照组的74.2%， 差异具有统计学意义 （P<0.05）。治疗前， 两组患者的血浆粘度、全血低切粘度、MARAA、MARADP水平比较， 差异均无统计学意义（P>0.05）;治疗后， 观察组患者的血浆粘度、全血低切粘度、MARAA、MARADP水平均低于对照组， 差异均具有统计学意义 （P<0.05）。治疗前， 两组患者的疼痛数字评分法（NRS）评分比较， 差异无统计学意义（P>0.05）;治疗后， 观察组患者的NRS评分为（1.36±0.22）分， 低于对照组的（3.52±1.11）分， 差异具有统计学意义 （P<0.05）。觀察组患者的头晕程度优于对照组， 差异具有统计学意义 （Z=3.9489， P<0.05）。治疗前， 两组患者的躯体功能、心理健康、情绪角色、社会功能评分比较， 差异均无统计学意义（P>0.05）;治疗后， 观察组患者的躯体功能、心理健康、情绪角色、社会功能评分均高于对照组， 差异均具有统计学意义 （P<0.05）。结论 对于脑梗死后头痛、头晕患者的治疗， 在西药常规治疗基础上联合养血清脑颗粒治疗， 对提高临床疗效、改善血液流变学、减低头痛头晕程度、提升生活质量方面有重大意义。

【关键词】 脑梗死;头痛头晕;养血清脑颗粒;临床效果

【Abstract】 Objective   To observe the clinical efficacy of Yangxue Qingnao granule on headache and dizziness after cerebral infarction. Methods   A total of 65 patients with headache and dizziness after cerebral infarction as study subjects were randomly divided into observation group （34 cases） and control group （31 cases）. The control group received conventional therapy， and the observation group received Yangxue Qingnao granule on the basis of conventional therapy. The clinical efficacy， hemorheological indexes [plasma viscosity， whole blood low shear viscosity， arachidonic acid induced platelet maximum aggregation rate （MARAA）， adenosine diphosphate induced platelet maximum aggregation rate （MARADP）] level before and after treatment， headache score and dizziness degree before and after treatment， and improvement of quality of life before and after treatment were compared between the two groups. Results   After treatment， the total effective rate was 94.1% in the observation group， which was higher than 74.2% in the control group， and the difference was statistically significant （P<0.05）. Before treatment， there was no statistically significant difference in levels of plasma viscosity， whole blood low shear viscosity， MARAA and MARADP between the two groups （P>0.05）. After treatment， the levels of plasma viscosity， whole blood low shear viscosity， MARAA and MARADP in the two groups were lower than those in the control group， and their difference was statistically significant （P<0.05）. Before treatment， there was no statistically significant difference in numerical rating scale （NRS） score between the two groups （P>0.05）. After treatment， the NRS score was （1.36±0.22） points in the observation group， which was lower than （3.52±1.11） points in the control group， and the difference was statistically significant （P<0.05）. The dizziness degree in the observation group was better than that in the control group， and the difference was statistically significant （Z=3.9489， P<0.05）. Before treatment， there was no statistically significant difference in scores of physical function， mental health， emotional role and social function between the two groups （P>0.05）. After treatment， the scores of physical function， mental health， emotional role and social function in the observation group were higher than those in the control group， and their difference was statistically significant （P<0.05）. Conclusion   For patients with headache and dizziness after cerebral infarction， Yangxue Qingnao granule on the basis of conventional therapy shows great significance in improving the clinical effect， improving hemorheology， reducing the degree of headache and dizziness， and improving the quality of life of patients.

【Key words】 Cerebral infarction; Headache and dizziness; Yangxue Qingnao granule; Clinical effect

脑梗死又称缺血性卒中， 是指各种脑血管病变所致脑部血液供应障碍导致局部脑组织缺血、缺氧性坏死， 而迅速出现相应神经功能缺损的一类综合征。脑梗死是卒中最常见的类型， 约占70%～80%， 对人类健康构成严重威胁。近年来， 在生活方式转变、饮食结构改变、行为习惯变化、人口老龄化等因素的推动下， 致使脑卒中发病率逐年攀升。随疾病进一步发展， 极易诱发诸多并发症， 对患者身心健康、生活质量产生严重影响。……