探讨应用阿托伐他汀治疗亚急性硬膜下血肿的疗效及安全性

黄安金

[摘要]目的 探讨阿托伐他汀治疗亚急性硬膜下血肿的临床效果。方法 选取2017年3月～2019年3月我院收治的亚急性硬膜下血肿50例，根据数字奇偶法分为观察组与对照组，每组各25例。对照组予以颅骨下血肿最厚处钻孔处理，观察组予以阿托伐他汀治疗，比较两组治疗效果、不良反应与复发情况、神经功能评分、日常生活活动能力评分。结果 观察组总有效率高于对照组，不良反应及复发率低于对照组，治疗后神经功能及日常生活活动能力评分低于对照组，差异有统计学意义（P<0.05）。结论 在亚急性硬膜下血肿患者治疗中应用阿托伐他汀不仅疗效确切，而且可以减少不良反应发生，降低复发率，神经功能得到改善，日常生活活动能力得到提升，具有显著临床价值。

[关键词]阿托伐他汀;亚急性硬膜下血肿;疾病复发;神经功能;日常生活活动能力;安全性

[中图分类号] R651.15          [文献标识码] A          [文章编号] 1674-4721（2020）5（a）-0037-03

Investigation on the efficacy and safety of Atorvastatin in the treatment of subacute subdural hematoma

HUANG An-jin

Department of Brain， Hospital of Torch Development Zone in Zhongshan City， Guangdong Province， Zhongshan   528400， China

[Abstract] Objective To investigate the clinical effect of Atorvastatin in the treatment of subacute subdural hematoma. Methods A total of 50 patients with subacute subdural hematoma in our hospital from March 2017 to March 2019 were divided into the observation group and the control group according to the digital parity method， 25 cases in each group. The control group was drilled at the thickest part of the skull hematoma， and the observation group was treated with Atorvastatin. The therapeutic effect， adverse reactions and recurrence， neurological function score and activity of daily life score of the two groups were compared. Results The total effective rate of the observation group was higher than that of the control group， the rates of adverse reactions and recurrence were lower than those of the control group， and the scores of neurological function and activities of daily life after treatment were lower than that of the control group， the differences were statistically significant （P<0.05）. Conclusion Atorvastatin is not only effective in the treatment of subacute subdural hematoma， but also can reduce the incidence of adverse reactions， reduce the recurrence rate， improve the neurological function， and improve the ability of daily life， which has significant clinical value.

[Key words] Atorvastatin; Subacute subdural hematoma; Disease recurrence; Neurological function; Activity of daily living; Safety

亞急性硬膜下血肿属于神经外科常见疾病之一，同时也是临床常见且多发疾病，指的是受伤后3 d至3周内硬膜下发生血肿现象[1-2]。这一疾病病情呈现出亚急性进展，这不仅会使颅内压增高，同时也会出现精神障碍，另外还会伴随局源性脑症状，对患者健康以及安全产生严重影响[3-4]。对于亚急性硬膜下血肿患者来说，钻孔引流是主要治疗方式，尽管此种方式可以取得一定效果，但术后有复发的可能，会使患者预后受到影响，所以需要对更加安全、有效的治疗方法进行探索，这对患者预后改善有重要意义[5-6]。本研究选取在我院治疗的50例亚急性硬膜下血肿作为研究对象，探讨在亚急性硬膜下血肿患者治疗中应用阿托伐他汀的效果及安全性，现报道如下。……