PRP注射联合自体脂肪移植的效果及对脂肪成活率的影响研究

刘小飞 汤育森

[摘要]目的：探讨富血小板血浆（Platelet-rich plasma，PRP）注射联合自体脂肪移植对移植脂肪成活率及移植效果的影响。方法：选取2018年1月-2018年12月在笔者医院进行面部改善的42例就医者作为本次研究对象，依据不同的治疗方式分为研究组与对照组，各21例。对照组采用自体脂肪双平面注射，观察组采用PRP注射结合自体脂肪移植。比较两组就医者并发症发生情况以及治疗效果。结果：研究组并发症发生率（9.52%，2/21）低于对照组（23.81%，5/21），差异有统计学意义（P<0.05）。研究组满意度高于对照组（95.24% vs 80.95%，P<0.05）。研究组面部凹陷、皱纹、皮肤松弛及脂肪组织坏死情况均低于对照组，差异有统计学意义（P<0.05）。结论：采用PRP注射联合自体脂肪移植能够显著改善移植脂肪的成活率以及移植效果，就医者在术后的面部轮廓得到显著改善，满意度较高，利于临床推广。

[关键词]富血小板血浆;自体脂肪移植;成活率;面部填充;面部年轻化

[中图分类号]R622    [文献标志码]A    [文章编号]1008-6455（2020）07-0067-03

Abstract： Objective  To investigate the effect of PRP （platelet-rich plasma，PRP）injection combined with autologous fat transplantation on the survival rate and transplantation effect of fat transplantation. Methods  Forty-two patients with facial improvement in our hospital from January 2018 to December 2018 were selected as the subjects of this study. According to different treatment methods， they were divided into the study group and the control group， with 21 cases in each group. The control group received biplane injection of autologous fat and facial filling， while the observation group received continuous PRP injection combined with biplane injection of autologous fat transplantation for facial filling. The complications of the two groups of patients and the therapeutic effects of the two groups of patients were compared. Results  The incidence of complications in the study group （9.52%， 2/21） was lower than that in the control group （23.81%， 5/21）， the difference was statistically significant（P<0.05）. The satisfaction of the study group was higher than that of the control group （95.24% vs 80.95%， P<0.05）. Facial depression， wrinkles， skin relaxation and adipose tissue necrosis in the study group were lower than those in the control group（P<0.05）. Conclusion  PRP injection combined with autologous fat transplantation can significantly improve the survival rate and transplantation effect of fat transplantation. The facial contour of patients after surgery is significantly improved with high satisfaction， which is conducive to clinical promotion.

Key words： platelet-rich plasma（PRP）; autologous fat transplantation; survival rate; facial filling; facial rejuvenation

近年來，社会经济水平不断提升的同时人们的生活质量状况得到明显改善，因此更加注重由于年龄增长而出现的凹陷、皱纹以及萎缩等面部老化情况[1]。在临床中面部年轻化方法相对较多，例如创伤相对较小的激光治疗、肉毒毒素注射、线雕除皱、软组织填充以及自体脂肪移植等。自体脂肪移植由于术后面部老化的情况显著改善、术区手感自然以及费用相对适中等特点而逐渐受到广大就医者的青睐[2-3]。富血小板血浆（Platelet-rich plasma，PRP）中含有较多的生长因子，进而为组织血管化情况的出现提供了优异的微环境，根据有关研究表明，对就医者进行PRP联合自体脂肪混合移植后，对于移植脂肪的成活率有显著促进作用[4-5]。本次研究通过对42例就医者的临床治疗，从而探究PRP注射对自体脂肪移植成活率以及移植效果的影响，现报道如下。……