合并糖尿病的毒性甲状腺肿患者内分泌疾病的治疗

张恩红

[摘要] 目的 探究合并糖尿病的毒性甲状腺肿患者内分泌疾病的临床用药及治疗效果。 方法 将该院于2018 年8月—2019年7月收治的50例毒性甲状腺肿合并糖尿病伴有内分泌眼病患者随机分为治疗组和对照组，各25例，分别加用环磷酰胺联合甲强龙治疗和给予常规药物治疗，比较两组临床治疗效果。 结果 治疗组治疗总有效率（96.00%）高于对照组（80.00%），比较差异有统计学意义（P<0.05）。治疗后，治疗组患者空腹血糖水平为（5.1±0.4）mmol/L，对照组为（6.7±0.7）mmol/L，治疗组低于对照组，差异有统计学意义（P<0.05）。 结论 在常规用药基础联合磷酰胺联合甲强龙冲击治疗毒性甲状腺肿合并糖尿病伴有内分泌眼病，疗效显著，安全性高。

[关键词] 糖尿病;毒性甲状腺肿;内分泌疾病

[中图分类号] R587.2          [文献标识码] A          [文章编号] 1672-4062（2020）05（b）-0029-03

Treatment of Endocrine Diseases in Patients with Diabetic Toxic Goiter

ZHANG En-hong

Department of Internal Medicine， the Fifth Hospital of Daqing， Daqing， Heilongjiang Province， 163711 China

[Abstract] Objective To explore the clinical application and therapeutic effect of endocrine diseases in patients with toxic goiter with diabetes. Methods Fifty patients with toxic goiter complicated with diabetes and endocrine eye disease from August 2019 to July 2019 in the hospital were randomly divided into a treatment group and a control group， with 25 cases in each group. They were treated with cyclophosphamide combined with methylprednisolone and given conventional drugs. The two groups were compared for clinical treatment effect. Results The total effective rate （96.00%） in the treatment group was higher than that in the control group （80.00%）， and the difference was statistically significant（P<0.05）. After treatment， the fasting blood glucose level in the treatment group was （5.1±0.4） mmol/L， and the control group was （6.7±0.7） mmol/L. The treatment group was lower than the control group， and the difference was statistically significant（P<0.05）. Conclusion Conventional medication based on combined use of phosphoramide and methylprednisolone in the treatment of toxic goiter with diabetes associated with endocrine eye disease has significant efficacy and high safety.

[Key words] Diabetes; Toxic goiter; Endocrine disease

糖尿病是當前社会中发病率较高的一种疾病，其主要特征是慢性高血糖，根治困难，一旦患有糖尿病，将会跟随患者终身。患者血糖如果长期处于偏高的状态，将会对患者其他身体脏器器官产生损害性影响。此外，糖尿病之所以得到医学界的广泛关注，还在于其并发症危害严重，根据世卫组织的统计，糖尿病并发症达到100多种，为全球疾病并发症种类之最。毒性甲状腺肿疾病是一种病因复杂的综合征疾病，临床研究及实践表明，其主要发病因素是过多的血肿甲状腺素造成的。毒性甲状腺肿疾病常常合并糖尿病疾病发作，进而会引发内分泌系统疾病，对患者的身体健康和生活质量造成极为严重的影响[1]。但是由于合并糖尿病的毒性甲状腺患者病情较为复杂，因而传统的治疗方式无法起到良好的治疗效果，这在医学研究和临床实践上也产生的较大的分歧和争议，因此寻找一种能够兼顾控制血糖水平和甲状腺功能调整的治疗方法显得十分的必要和紧迫。……