重症糖尿病患者应用胰岛素泵治疗的临床研究

2020-08-06 14:31:40吕宇基卢国圣
糖尿病新世界 2020年10期

吕宇基 卢国圣

[摘要] 目的 探析对重症糖尿病患者行以胰岛素泵治疗的临床效果。方法 从2018年12月—2019年12月择取150例重症糖尿病患者,将其随机分组研究,对照组(75例)患者行以胰岛素注射治疗,研究组(75例)患者行以胰岛素泵治疗,对照分析两组临床效果。 结果 研究组起效时间比对照组早,胰岛素使用剂量比对照组少(P<0.05);治疗前两组患者的空腹血糖水平、餐后2 h血糖水平、糖化血红蛋白水平对比差异无统计学意义(P>0.05),治疗后研究组空腹血糖水平、餐后2 h血糖水平、糖化血红蛋白水平低于对照组(P<0.05)。研究组血糖达标时间比对照组早,达标率比对照组高,酮体转阴时间比对照组早,住院时间比对照组短,低血糖反应发生率比对照组低(P<0.05)。 结论 对于重症糖尿病患者来说,通过胰岛素泵进行治疗,可以缩短起效时间,减少胰岛素使用剂量,促进血糖水平改善,临床价值显著。

[关键词] 重症糖尿病;胰岛素泵;临床效果

[中图分类号] R587.1          [文献标识码] A          [文章编号] 1672-4062(2020)05(b)-0036-03

Clinical Study of Insulin Pump Treatment in Patients with Severe Diabetes

LYU Yu-ji, LU Guo-sheng

Department of Internal Medicine, Fengkai County Traditional Chinese Medicine Hospital, Zhaoqing, Guangdong Province, 526500 China

[Abstract] Objective To analyze the clinical effect of insulin pump therapy on patients with severe diabetes. Methods From December 2018 to December 2019, 150 patients with severe diabetes were selected and randomly divided into groups. The control group (75 patients) received insulin injection therapy, and the study group (75 patients) received insulin pump treatment, control analysis of clinical effects of the two groups. Results The onset time of the study group was earlier than that of the control group, and the dosage of insulin was less than that of the control group(P<0.05). There was no statistical difference in the fasting blood glucose level, 2 h postprandial blood glucose level, and glycated hemoglobin level between the two groups of patients(P>0.05). After treatment, the fasting blood glucose level, 2 h postprandial blood glucose level, and glycated hemoglobin level in the study group were lower than those in the control group(P<0.05). The blood glucose reaching time of the study group was earlier than that of the control group, and the rate of achieving the standard was higher than that of the control group. The time of ketone body turning negative was earlier than that of the control group. Conclusion For patients with severe diabetes, treatment with an insulin pump can shorten the onset time, reduce the dosage of insulin, promote the improvement of blood glucose levels, and have significant clinical value.

[Key words] Severe diabetes; Insulin pump; Clinical effect

糖尿病屬于临床常见疾病,同时也是世界性公共卫生问题之一,威胁人们健康。近些年,这一疾病发生率呈现出递增趋势[1]。如果患者未得到及时有效的治疗及干预,则容易发生代谢酸中毒、高酮血症、高血糖等症状,且向重症糖尿病发展。临床中,对于糖尿病患者的治疗主要以胰岛素为主,通过胰岛素治疗可以控制患者血糖水平,但据相关研究指出,对于已经确诊的糖尿病,60%以上的患者因胰岛素使用不足而影响血糖控制效果。传统治疗方式为皮下注射,此种方式操作不便,胰岛素注入速度很难有效控制,而且容易出现明显的血糖波动现象,因此效果不理想,而且还容易诱发低血糖[2]。而胰岛素泵可以通过持续皮下输注胰岛素进行治疗,利用模拟人体胰岛素分泌的模式,使机体胰岛素水平维持稳定状态,使机体生理需求得到充分满足,达到降糖的目的,效果确切[3]。该文从2018年12月—2019年12月择取150例重症糖尿病患者进行研究,探析对重症糖尿病患者行以胰岛素泵治疗的临床效果,现报道如下。……

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