二甲双胍联合胰岛素治疗老年糖尿病的临床疗效及预后分析

王珍贵

[摘要] 目的 二甲雙胍联合胰岛素治疗老年糖尿病的临床疗效及预后分析。方法 选择该院在2017年5月—2019年5月之间收治的120例患者进行调查与分析，将患者分为2组，每组60例。对比组采用常规治疗方式，实验组运用二甲双胍与胰岛素联合治疗方式。分析两组患者治疗前后血糖改善情况、HbA1c、血脂情况。 结果 ①对比组胰岛素使用剂量和实验组相比较高，两组差异有统计学意义（t=10.697，P=0.000）;②对比组血糖达标时间和实验组相比较长，两组差异有统计学意义（t=105.772，P=0.000）;③对比组空腹血糖水平和实验组相比较高，餐后2 h血糖水平和实验组相比较高，两组差异有统计学意义（t=5.068、4.150，P=0.000、0.000）;④对比组HbA1c水平和实验组相比较高，两组差异有统计学意义（t=3.343，P=0.001）。结论 在老年糖尿病病人治疗中，可以采用二甲双胍与胰岛素联合治疗方式，可有效的改善血糖水平，提高治疗效果。

[关键词] 糖尿病;老年;胰岛素;二甲双胍

[中图分类号] R4          [文献标识码] A          [文章编号] 1672-4062（2020）05（b）-0054-03

Clinical Efficacy and Prognosis of Metformin Combined with Insulin in the Treatment of Senile Diabetes

WANG Zhen-gui

Fulaishan Sub-district Medical Center， Juxian， Rizhao， Shandong Province， 276511 China

[Abstract] Objective To analyze the clinical efficacy and prognosis of metformin combined with insulin in the treatment of senile diabetes. Methods A total of 120 patients admitted to the department between May 2017 and May 2019 were selected for investigation and analysis. The patients were divided into 2 groups of 60 patients each. The control group was treated with conventional treatment， and the experimental group was treated with metformin and insulin. Analysis of blood glucose improvement， HbA1c， and lipids before and after treatment in the two groups of patients. Results 1.The dosage of insulin in the comparison group was higher than that in the experimental group， and the differences between the two groups were statistically significant（t=10.697， P=0.000）; 2.The blood glucose compliance time in the comparison group was longer than that in the experimental group， and the differences between the two groups were statistically significant（t=105.772， P=0.000）; 3.The fasting blood glucose level in the comparison group was higher than that in the experimental group， and the blood glucose level at 2 hours after meal was higher than that in the experimental group. The differences between the two groups were statistically significant（t=5.068， 4.150， P=0.000， 0.000）;4.The HbA1c level in the comparison group is higher than that in the experimental group， and the differences between the two groups are statistically significant（t=3.343， P=0.001）. Conclusion In the treatment of elderly diabetic patients， the combined treatment of metformin and insulin can effectively improve blood glucose levels and improve the treatment effect.

[Key words] Diabetes; Elderly; Insulin; Metformin

现如今随着老龄化人口的日渐增多，各种与老年有关疾病的发生率也属于上涨趋势，老年糖尿病的发生率也有明显增高趋势[1]。老年人自身机体功能本就处于下降趋势，再加上糖尿病所带来的诸多困扰，给患者的生活质量以及生命安全均造成严重威胁[2-3]。为此，要对其实施针对有效的治疗，在以往的治疗中，糖尿病治疗以胰岛素治疗为主，虽然这种药物可以明显改善临床症状，但效果不是十分的理想[4]。二甲双胍是属于双肌类的药物，具有减少肝脏输出葡萄糖的能力，可以帮助脂肪细胞、肌肉细胞和肝脏从血液中汲取更多的葡萄糖，降低患者的血糖水平，是临床上常用的降血糖药物[5-6]。……