阿卡波糖联合二甲双胍治疗2型糖尿病的效果

于晓红

[摘要] 目的 分析在2型糖尿病治疗中阿卡波糖与二甲双胍的联合应用价值。方法 随机选择78例从2017年1月—2019年5月于该院接受诊治并确诊为2型糖尿病的患者纳为该次研究对象，并通过奇偶数数字抽签法将其随机分为两组（参照组与试验组）进行区别性治疗，每组39例。仅采用二甲双胍对参照组患者进行单一性常规给药，对试验组患者则在前者的基础上联合阿卡波糖对其进行联合治疗，而后对比分析两组患者的临床疗效以及血糖指标与血脂指标情况。 结果 综合分析研究结果可知，试验组患者的临床治疗总有效率92.31%明显高于参照组患者的临床治疗总有效率74.36%，且相关数据差异有统计学意义（P<0.05）。此外，两者亦在血糖指标与血脂指标的相关数据比较，试验组均低于参照组，差异有统计学意义（P<0.05）。结论 在应用二甲双胍对2型糖尿病患者进行单一性常规治疗的同时加用阿卡波糖进行联合治疗，不仅能够快速降低患者的血糖与血脂水平，并且还可不断提升临床疗效。

[关键词] 阿卡波糖;二甲双胍;2型糖尿病;血糖指标

[中图分类号] R587.1          [文献标识码] A          [文章编号] 1672-4062（2020）05（b）-0057-03

Effect of Acarbose Combined with Metformin in the Treatment of Type 2 Diabetes

YU Xiao-hong

Outpatient Department of Shandong Dongying Supply Community Health Service Center， Dongying， Shandong Province， 257000 China

[Abstract] Objective To analyze the combined application value of acarbose and metformin in the treatment of type 2 diabetes. Methods A total of 78 patients who were diagnosed and diagnosed with type 2 diabetes in the hospital from January 2017 to May 2019 were randomly selected as the subjects of this study， and they were randomly divided into two groups by the odd-even number drawing method （the reference group and the test group） were treated differently， with 39 cases in each group. Only metformin was used for routine single-dose administration in patients in the reference group， while patients in the test group were treated with acarbose in combination with the former， and then the clinical efficacy of the two groups of patients were compared and analyzed. Results Comprehensive analysis of the research results showed that the total effective rate of clinical treatment of patients in the test group was 92.31% significantly higher than the total effective rate of clinical treatment of patients in the reference group， 74.36%， and the relevant data were statistically significant （P<0.05）. In addition， the two also have statistical differences in blood glucose and lipid related data，both in the experimental group was lower than the reference group（P<0.05）. Conclusion The combined use of metformin for single-type conventional treatment of patients with type 2 diabetes mellitus combined with acarbose can not only rapidly reduce the patients' blood glucose and blood lipid levels， but also continuously improve the clinical efficacy.

[Key words] Acarbose; Metformin; Type 2 diabetes; Blood glucose indicators

從医学的角度来看，2型糖尿病即由人体胰岛素分泌缺陷或胰岛素作用障碍所致的以高血糖为特征且具有遗传易感性，易在环境因素的影响下发病的内分泌代谢性疾病[1-2]。据WHO的相关调查结果显示，当前，人类生活水平的提高促使其饮食作息等生活习惯不断改变，导致2型糖尿病的发病率呈逐年上升的不利趋势。此外，由于该疾病的并发症涉及较广且发生率较高，若不及时控制其血糖与血脂水平，则极有可能引发其他重大疾病，严重危害患者的生命健康。大量临床相关资料显示，目前临床用以控制2型糖尿病患者空腹血糖、餐后血糖以及尿糖等综合血糖水平的常用药物主要为胰岛素促泌药与α-葡萄糖苷酶抑制药两大类，然而该疾病患者各方面存在一定的个体差异性，故而具体如何进行给药务必要以其临床实际情况为出发点。……