骨疏宁片的药学及临床应用研究概况

【摘 要】  骨疏宁片具有益阴助阳、补肾壮骨、养血化瘀、通络镇痛之功效，主治原发性骨质疏松症，效果显著，治疗骨折、腰椎间盘突出症、膝关节病、继发型骨质疏松症也有明显疗效。文章主要对骨疏宁片的质量控制、药理作用和临床应用进行综述，以期为今后对骨疏宁片的进一步研究和推广应用提供理论依据。

【关键词】  骨疏宁片;制备;薄层鉴别;药理作用;临床应用

【中图分类号】R285.6   【文献标志码】A    【文章编号】1007-8517（2020）11-0043-03

Pharmaceutical and Clinical Application of Gushuning Tablets

WU Yongmei

Hospital Pharmacy Department of integrated traditional Chinese and Western medicine in Yulin，Yulin 537000，China

Abstract： Gushuning tablet has the effects of benefiting Yin and Yang， tonifying kidney and strengthening bone， nourishing blood and removing blood stasis， dredging collaterals and relieving pain. It is mainly used to treat primary osteoporosis with significant effect. It also has obvious effect in treating fracture， lumbar disc herniation， knee joint disease and subsequent osteoporosis. In this paper， the quality control， pharmacological action and clinical application of gushuning tablets were reviewed， which provided theoretical basis for further research and application of gushuning tablets in the future.

Key words： Gushuning Tablet; Preparation; TLC Identification; Pharmacological Action; Clinical Application

骨疏寧片为中药复方制剂，其主要成分为淫羊藿、枸杞子、肉苁蓉、菟丝子、仙茅、丹参、巴戟天、续断、杜仲、狗脊、骨碎补等，具有益阴助阳、补肾壮骨、养血化瘀、通络镇痛之功效。方中淫羊藿补肾壮骨;枸杞子滋阴补肾，乃阴中之阳药;肉苁蓉补肾益精，润燥滑肠;菟丝子补肾填精;仙茅温阳补肾;丹参活血化瘀;巴戟天温肾壮阳;续断、杜仲补肾壮腰，通络止痛;独活通经活络，蠲痹止痛;狗脊、骨碎补补肾填精，壮腰健骨;诸药合用以达补阴助阳、补肾填精、壮骨增髓之效[1]。骨疏宁片主治骨质疏松症，疗效确切。笔者对骨疏宁片的质量控制、药理作用和临床应用研究情况综述如下。

1 制备方法及质量控制

林琼芳等[2]采用传统工艺将部分药材粉碎成细粉，部分药材水提浓缩成稠膏，加入细粉混匀，干燥，粉碎，制成片剂。 从性状、鉴别、检查项目控制骨疏宁片的质量，鉴别方法采用单一成分的定性鉴别，通过乙醚水浴回流提取，薄层色谱法鉴别山茱萸中的熊果酸成分，质量标准较简单。……