艾司奥美拉唑联合甘桔冰梅片治疗反流性咽喉炎的疗效

贾芳　崔颖　吴超颖　李倩云　黄子瑞

摘要：目的  探讨艾司奥美拉唑联合甘桔冰梅片治疗反流性咽喉炎的临床疗效。方法  选取2018年7月～2019年7月我院收治的135例咽喉反流性疾病患者，按照随机数字表法分为单独治疗组（67例）和联合治疗组（68例）。单纯治疗组仅口服艾司奥美拉唑肠溶片治疗，联合治疗组在单独治疗组基础上联合甘桔冰梅片治疗，比较两组治疗前后咽喉反流症状指数评分量表（RSI）、反流体征评分量表（RFS）及治疗有效率。结果  治疗后4、8周，两组RSI、RFS评分较治疗前降低，联合治疗组RFS、RSI评分低于单独治疗组，差异有统计学意义（P<0.05）。联合治疗组总有效率为94.12%，高于单纯治疗组的91.04%，差异有统计学意义（P<0.05）。联合治疗组不良反应发生率低于单独治疗组，但差异无统计学意义（P>0.05）。结论  艾司奥美拉唑联合甘桔冰梅片治疗反流性咽喉炎疗效确切，可有效改善临床症状，且不增加不良反应发生率。

关键词：反流性咽喉炎;艾司奥美拉唑;甘桔冰梅片

中图分类号：R767.11                                文獻标识码：A                                DOI：10.3969/j.issn.1006-1959.2020.14.048

文章编号：1006-1959（2020）14-0153-02

Efficacy of Esomeprazole Combined with Ganju Bingmei Tablets

in the Treatment of Reflux Pharyngitis

JIA Fang，CUI Ying，WU Chao-ying，LI Qian-yun，HUANG Zi-rui

（Otorhinolaryngology Head and Neck Surgery，the First Affiliated Hospital of Jinzhou Medical University，

Jinzhou 121000，Liaoning，China）

Abstract：Objective  To explore the clinical efficacy of Esomeprazole combined with Ganju Bingmei tablets in the treatment of reflux pharyngitis. Methods  A total of 135 patients with throat reflux disease admitted to our hospital from July 2018 to July 2019 were selected and divided into a simple treatment group （67 cases） and a combined treatment group （68 cases） according to the random number table method. The simple treatment group only received oral administration of Esomeprazole enteric-coated tablets， and the combined treatment group was combined with the Ganju Bingmei tablets on the basis of the simple treatment group. The throat reflux symptom index score scale （RSI）， Reflux Sign Rating Scale （RFS） and treatment effectiveness.Results  At 4 and 8 weeks after treatment， the RSI and RFS scores of the two groups were lower than before treatment. The RFS and RSI scores of the combined treatment group were lower than those of the single treatment group，the difference was statistically significant （P<0.05）. The total effective rate in the combination treatment group was 94.12%， higher than 91.04% in the simple treatment group，the difference was statistically significant （P<0.05）. The incidence of adverse reactions in the combined treatment group was lower than that in the single treatment group， but the difference was not statistically significant （P>0.05）.Conclusion  Esomeprazole combined with Ganju Bingmei Tablets has definite curative effect on the treatment of reflux pharyngitis， which can effectively improve the clinical symptoms without increasing the incidence of adverse reactions.

Key words：Reflux pharyngitis;Esomeprazole;Ganju Bingmei tablets

咽喉反流（laryngopharyngeal reflux，LPR）或反流性咽喉炎是与胃内容物反流至食管上端括约肌相关的慢性咽喉炎，可引起声嘶、咽痛、咽部异物感、持续清嗓、咳嗽、呼吸困难、喉痉挛、哮喘、慢性鼻窦炎，严重者甚至导致喉癌，严重影响患者生活质量[1，2]。目前临床表现的反流性咽喉炎症状及体征并无特异性，诊断反流性咽喉炎主要依据咽喉反流症状指数量表（RSI）、反流体征指数量表（RFS），其源于我国专家于2015年制定的《咽喉反流性疾病的诊断与治疗指南》[3]，抑酸治疗作为常用的治疗方案，首选药物为PPI类药物，但此类药物仅单纯抑制了胃内容物的反流，并不能够改善局部的咽喉炎症状。……