丹栀逍遥散加减联合艾司唑仑治疗糖尿病合并失眠临床观察

刘雯涓 戴秀娟

[摘要] 目的 探讨对糖尿病合并失眠患者应用中药丹栀逍遥散加减联合艾司唑仑的治疗效果。方法 选取2017年9月—2019年9月于该院就诊的糖尿病合并失眠患者64例，将其随机分为对照组与研究组，各32例，对照组单纯给予艾司唑仑进行治疗，研究组在对照组基础上联合应用丹栀逍遥散加减加减，连续用药4周后停药1周，比较两组疗效及睡眠质量。结果 研究组临床治愈率37.5%，高于对照组9.4%;总有效率93.8%，高于对照组71.9%，差异有统计学意义（P<0.05）。结论 丹栀逍遥散加减联合艾司唑仑较单纯应用艾司唑仑可显著提高糖尿病合并失眠患者治疗效果，改善患者睡眠治疗。

[关键词] 丹栀逍遥散;艾司唑仑;糖尿病;失眠

[中图分类号] R587.2          [文献标识码] A          [文章编号] 1672-4062（2020）06（a）-0059-03

[Abstract] Objective To explore the therapeutic effect of applying Chinese medicine Danzhi Xiaoyao powder combined with estazolam to diabetic patients with insomnia. Methods 64 patients with diabetes mellitus and insomnia who were treated in the hospital from September 2017 to September 2019 were selected and randomly divided into a control group and a study group of 32 cases each. The control group was given eszolen for treatment only. The study group combined with Danzhi Xiaoyao powder addition and subtraction on the basis of the control group. After 4 weeks of continuous medication， the drug was stopped for 1 week. The efficacy and sleep quality of the two groups were compared. Results The clinical cure rate of the study group was 37.5%， higher than the control group 9.4%; the total effective rate was 93.8%， higher than the control group 71.9%， the differences were statistically significant（P<0.05）. Conclusion The addition and subtraction of Danzhi Xiaoyao powder combined with estazolam can significantly improve the treatment effect of patients with diabetes and insomnia and improve the sleep treatment of patients with diabetes compared with the simple application of estazolam.

[Key words] Danzhi Xiaoyao powder; Estazolam; Diabetes; Insomnia

近年來随着人们生产生活方式和饮食结构的改变，糖尿病发病人数不断增多，据统计，我国18岁以上成年人，2型糖尿病发病率达10.4%，60岁以上老年人患病率达20%以上[1]。其中失眠是糖尿病患者较易并发的常见疾病之一，糖尿病患者血糖长期处于较高水平，血黏度增高、血流速度减慢，微小血管血流不畅，神经营养供应不足，从而导致神经紊乱，产生失眠的症状[2]。目前西医治疗失眠主要应用苯二氮卓类药物，但长期应用不良反应较多，易形成耐受，且停药后病情容易反弹[3]。该研究选取2017年9月—2019年9月于该院就诊的糖尿病合并失眠患者64例，应用中药方剂丹栀逍遥散加减联合艾司唑仑进行干预，探讨中西医结合治疗糖尿病合并失眠的临床效果，现报道如下。

1  资料与方法

1.1  一般资料

选取于该院就诊的糖尿病合并失眠患者64例，患者年龄54～78岁，平均（69.6±3.6）岁，其中男33例，女31例，糖尿病病程5～26年，平均（10.1±2.7）年，失眠病程1个月～4年，平均（1.3±0.4）年。……