调中饮对功能性消化不良患儿胃肠激素和胃电图的影响

嵇玉华 吴红波

摘要 目的：探討调中饮对功能性消化不良（FD）患儿胃肠激素和胃电图的影响。方法：选取2014年8月至2017年8月烟台市烟台山医院收治的FD患儿123例作为研究对象，按照随机数字表法随机分为对照组（n=61）与观察组（n=62）。对照组进行常规治疗，观察组在对照组基础上采用调中饮治疗，2组均连续治疗1个月。比较2组临床疗效及主要中医症状积分;比较2组治疗前后胃肠激素及胃电图变化。结果：治疗后观察组总有效率（85.48%）显著高于对照组（72.13%）（P<0.01）。与治疗前比较，治疗后2组患儿腹胀、上腹灼热、腹痛、嗳气、恶心呕吐等症状积分及血清SS含量均显著降低，且观察组低于对照组（P<0.05或P<0.01）;而血清MLT、GAS、SP含量显著升高，且观察组MLT与SP含量高于对照组（P<0.05或P<0.01）;与治疗前比较，治疗后2组患儿FP、正常慢波比率水平及正常胃电节律患儿比例均显著升高，且观察组高于对照组（P<0.05或P<0.01）;而胃电节律过缓患儿比例显著下降，且观察组低于对照组（P<0.05或P<0.01）。结论：调中饮治疗儿童FD可显著缓解患儿临床症状，促进胃肠激素水平恢复正常，同时可有效改善胃电图，临床疗效良好。

关键词 功能性消化不良;调中饮;胃肠激素;胃电图

Abstract Objective：To study the effects of Tiaozhong Drink on gastrointestinal hormone and electrogastrogram in functional dyspepsia（FD）children.Methods：A total of 123 FD child patients admitted to Yantai Mountain Hospital of Yantai were selected as the research objects and randomly divided into an observation group（n=62）and a control group（n=61）.The control group was given conventional chemotherapy，and the observation group was treated with Tiaozhong Drink for on the basic of control group.Both 2 groups were treated continuously for 1 month.The clinical efficacy and scores of main TCM symptoms in 2 groups of child patients were compared; the gastrointestinal hormones and electrogastrogram changes before and after treatment in 2 groups were also compared.Results：After treatment，the total effective rate of the observation group（85.48%）was significantly higher than that of the control group（72.13%）（P<0.01）.Compared with those before treatment，the symptoms scores of abdominal distention，abdominal scorching hot，abdominal pain，belching，nausea and vomiting and serum content decreased significantly in 2 groups after treatment，and observation group was significantly lower than control group（P<0.05 or P<0.01）; and the serum MLT，GAS and SP content increased significantly and the MLT and SP contents in observation group were significantly higher than those in control group（P<0.05 or P<0.01）; compared with those before treatment，the levels of FP，normal slow wave ratio and the proportion of child patients with normal gastric electrical rhythm in 2 groups after treatment increased significantly，and observation group was significantly higher than the control group（P<0.05 or P<0.01）; and the proportion of children with slow gastric rhythm decreased significantly，and observation group was significantly lower than the control group（P<0.01）.Conclusion：Tiaozhong Drink in the treatment of children with FD can significantly relieve the clinical symptoms of child patients，promote the recovery of gastrointestinal hormone levels，and effectively improve the electrogastrogram，with good clinical effects.

Keywords Functional dyspepsia; Tiaozhong Drink; Gastrointestinal hormone; Electrogastrogram

中图分类号：R272文献标识码：Adoi：10.3969/j.issn.1673-7202.2020.17.019

功能性消化不良（Functional Dyspeps，FD）是儿科常见的消化道疾病，患儿以持续或间歇性腹胀、腹痛、嗳气、恶心呕吐等为主要临床表现，正常生长发育及日常生活受到严重影响[1]。研究[2-3]表明，FD的发病与患儿胃动力不足紧密相关，西医常采用促胃肠动力类药物进行治疗，以期改善其临床症状，但患者病情易反复，治疗效果不佳。中医将FD归属为“积滞”“痞满”的范畴，认为脾虚肝郁、胃失和降是其发病机制，因此治疗中应遵守疏肝健脾、调和胃气的治疗原则。调中饮出自《温热暑疫全书》卷一，主治食积类伤寒、手足四肢发阴斑等[4-5]。本研究着重探讨调中饮治疗功能性消化不良儿童的疗效及对患儿胃肠激素和胃电图的影响。现将结果报道如下。

1 资料与方法

1.1 一般资料 选取2014年8月至2017年8月于烟台市烟台山医院就诊的FD患儿123例作为研究对象，按照随机数字表法随机分为观察组（n=62）与对照组（n=61）。……