重组人脑利钠肽与传统药物对急性心力衰竭治疗效果及不良反应的分析

程明月 张辉 燕军 冯辉

【摘要】目的：分析在急性心力衰竭患者治疗过程中分别使用重组人脑利钠肽与传统药物所取得的临床效果。方法：在2019年1月至2020年12月徐州医科大学附属医院收治的急性心力衰竭患者中选取60例分为两组，对照组使用传统药物治疗，研究组使用重组人脑利钠肽治疗，将两组患者的治疗效果加以分析。结果：在治疗有效率方面，研究组明显高于对照组。经治疗，患者心功能指标均出现明显的改善，且研究组与对照组比较，明显更优;患者临床体征指标均有所改善，且研究组优于对照组;研究组不良反应率低于对照组;患者生活质量均得到了合理提升，且研究组高于对照组;研究组治疗满意度高于对照组，所有数据经比较，差异具有统计意义（P <0.05）。结论：在急性心力衰竭患者治疗过程中，重组人脑利钠肽能够改善患者的心功能，促进患者预后，有利于推动患者健康的进一步维系，该治疗模式值得推广。

【关键词】心内科;急性心力衰竭;药物治疗;重组人脑利钠肽;心功能水平

【中图分类号】R541.7【文献标识码】A 【文章编号】2096-5249（2021）22-0023-03

Therapeutic effects and adverse reactions of recombinant human brain natriuretic peptide and traditional drugs on acute heart failure

Cheng Ming-yue， Zhang Hui， Yan Jun， Feng Hui

A?liated Hospital ofXuzhou Medical University， Xuzhou 221000， China

【Abstract】Objective：To analyze the clinical e?ects of recombinant human brain natriuretic peptide and traditional drugs in the treatment of patients with acute heart failure.Methods：From January 2019 to December 2020，60 patients with acute heart failure were selected and divided into two groups.The control group was treated with traditional drugs，and the study group was treated with recombinant human brain natriuretic peptide.The therapeutic e?ects of patients were compared and analyzed.Results：The e?ective rate ofthe study group was higher than that ofthe control group.After treatment，the indexes of cardiac function were improved，and the study group was better than the control group.After treatment，the clinical signs of the patients were improved，and the study group was better than the control group.The adverse reaction rate of the study group was lower than that of the control group.After treatment，the quality of life of patients has been reasonably improved，and the study group is higher than the control group.The treatment satisfaction of the study group was higher than that of the control group.After comparison，all data were P<0.05，indi- cating that the di?erence was statistically signi?cant.Conclusion：In the treatment of patients with acute heart failure，recombinant human brain natriuretic peptide can better help patients achieve the improvement of cardiac function，promote the improvement of patientsprognostic health level，and promote the maintenance of patientshealth.This treatment model is worthy of promotion.

【Key words】Cardiology;Acute heart failure;Medication;Recombinant human brain natriuretic peptide;Cardiac function level

相關数据显示，在心内科临床过程中，急性心力衰竭严重影响患者的身体健康。总的来看，由于受到该病的影响患者出现心脏输出量降低，从而不利于患者机体血液灌注需求的有效满足，若不能及时进行合理纠正，则往往会对患者生命安全构成严重威胁[1]。急性心力衰竭的发病机制相对较为复杂，就目前而言，临床领域对于这一问题仍处于探索过程中。有研究人员指出，急性心力衰竭可能与患者醛固酮、血管紧张素以及交感神经系统的过度激活具有一定关联性[2]。对于患者而言，该病患者早期可出现运动耐受力降低、疲惫、心率增加以及呼吸受限等症状，在此阶段，应及时依据患者实际情况给予药物治疗，使患者心功能得到明显的改善。……