老年肺栓塞患者华法林长期抗凝治疗的效果和安全性分析

徐丽江

【摘要】目的：分析老年肺栓塞患者采用华法林长期抗凝治疗的临床效果以及安全性。方法：选取研究对象为老年肺栓塞患者42例，选择分组方法为随机数字表法。将选定患者平均分为观察组和对照组，对两组患者治疗后的临床疗效、并发症发生率进行对比分析。结果：（1）两组患者临床疗效对比：数据表明，观察组患者临床疗效为90.4%，明显高于对照组患者的76.1%，两组患者对比统计学差异明显（P<0.05）。（2）分析两组患者并发症发生率：数据表明，观察组患者牙龈出血、结膜出血、咯血总发生率明显低于对照组患者，对比统计学差异明显（P<0.05）。结论：在老年肺栓塞患者的临床治疗中采用华法林长期治疗更有利于提高患者临床疗效，治疗期间并发症发生率更低，安全性更高，值得临床推广及普及。

【关键词】老年肺栓塞;华法林;抗凝;安全性

[中图分类号]R563.5[文献标识码]A[文章编号]2096-5249（2021）21-070-02

Effect and Safety ofLong-term Anticoagulant Therapy with Warfarin in Elderly Patients with Pulmonary Embolism

XU Li-jiang（Beijing Yanhua Hospital， Beijing 102500， China）

[Abstract] Objective： To analyze the clinical effect and safety of long-term anticoagulant therapy with warfarin in elderly patients with pulmonary embolism. Methods：42 elderly patients with pulmonary embolism were selected as subjects， It was divided into observation group and control group according to random number table method， The clinical effect and complication rate of the two groups were compared and analyzed. Results：（1）Comparison of clinical efficacy between the two groups： data showed that， The clinical efficacy of the patients in the observation group was 90.4%， significantly higher than 76.1%in the control group， Compared with the two groups， the difference was significant（P<0.05）.（2）Analysis of the incidence of complications between the two groups： data show that， The total incidence of gingival bleeding， conjunctival bleeding and hemoptysis in the observation group was significantly lower than that in the control group， Compared with the statistical difference（P<0.05）. Conclusion： The long-term treatment of warfarin in elderly patients with pulmonary embolism is more beneficial to improve the clinical efficacy， Lower incidence of complications during treatment， More secure， It is worthy of wide clinical application.

[Key words]senile pulmonary embolism;warfarin;anticoagulant;safety

肺栓塞是指由于內源性以及外源性栓子栓塞肺动脉或其分支引起的肺循环障碍以及右心功能障碍现象。据统计，近年来，由于群众生活方式的变化以及大气污染，导致肺栓塞发病率逐年增长。老年肺栓塞患者可合并多种疾病，给临床的治疗增加了难度，同时，部分老年患者由于身体体质低下，在治疗中容易出现出血等情况[1]。因此，如何在有效提高患者临床疗效的同时降低患者出血几率是临床关注的重点。华法林是一种用于栓塞治疗的药物，能够有效改善患者临床症状，也可用于肺栓塞患者长期抗凝治疗，提高患者疗效[2]。……