GATA-3、AR在非三阴与三阴性乳腺癌中的表达及与临床病理特征的相关性

夏云 陶珊珊 桂星星 瞿伟 涂剑宏

[摘要] 目的 探讨GATA结合蛋白3（GATA-3）、雄激素受体（AR）在非三阴性与三阴性乳腺癌中的表达差异及两者的表达与临床病理特征的关系。 方法 收集本院2019年1月至2020年12月确诊的200例乳腺癌患者，其中非三阴性（Non-TNBC）100例和三阴性（TNBC）100例，采用免疫组织化学法检测患者GATA-3、AR的表达情况，对比两者在非三阴性和三阴性乳腺癌中的表达差异及其与乳腺癌临床病理特征的相关性。 结果 非三阴性和三阴性患者的年龄、肿瘤大小、淋巴结转移、脉管转移等比较，差异均无统计学意义（P>0.05），与组织学分级呈相关性（P<0.05）。GATA-3在非三阴性的表达率为99%，在三阴性患者表达率为84%，差异有统计学意义（P<0.05）。AR在非三阴性乳腺癌的表达率为97%，在三阴性表达率为36%，差异有统计学意义（P<0.05）。 结论 GATA-3、AR在非三阴性乳腺癌患者的阳性表达率明显高于三阴性患者，三阴性乳腺癌患者组织学分级更高。

[关键词] GATA-3;AR;非三阴性乳腺癌;三阴性乳腺癌

[中图分类号] R737.39          [文献标识码] A          [文章编号] 1673-9701（2021）31-0012-04

[Abstract] Objective To explore the differences in the expression of GATA-binding protein 3 （GATA-3） and androgen receptor （AR） in non-triple-negative and triple-negative breast cancer， and to investigate the correlation between their expressions and clinicopathological features. Methods A total of 200 breast cancer patients， including 100 non-triple negative（Non-TNBC） and 100 triple negative（TNBC） cases， admitted to our hospital from January 2019 to December 2020 were collected， and the expressions of GATA-3 and AR in patients were determined by immunohistochemistry. The differences between their expressions in non-triple negative and triple negative breast and their correlation with clinicopathological features of breast cancer were compared. Results There was no significant differences in age， tumor size， lymph node metastasis， and vasculature metastasis in the non-triple negative and triple negative patients（P>0.05）.It showed the expressions were correlated to histological grade（P<0.05）. The expression rate of GATA-3 in non-triple-negative patients was 99% and the expression rate in triple-negative patients was 84%，with statistically significant difference（P<0.05）.The expression rate of AR in non-triple breast cancer was 97% and the expression rate in triple-negative patients was 36%， with statistically significant difference（P<0.05）. Conclusion The positive expression rates of GATA-3 and AR are significantly higher in non-triple-negative patients than those in triple-negative breast cancer patients， and the histological grade of triple-negative breast cancer patients is higher.

[Key words] GATA-3; AR; Non-triple-negative breast cancer; Triple-negative breast cancer

乳腺癌是一種高度异质性肿瘤，在女性恶性肿瘤发病率中居第一位[1]。其中依据ER、PR、HER-2、Ki-67的表达，可被分为4种亚型：Luminal A型、Luminal B型、HER-2过表达型和三阴性乳腺癌，其中ER-、PR-、HER-2-即为三阴性乳腺癌。Burstein等[2]通过基因组分析，进一步将三阴性乳腺癌细分为腔型雄激素受体型（Luminal androgen receptor，LAR）、间质型（Mesenchymal，MES）、基底样免疫抑制型（Basal-like immune-suppressed，BLIS）、基底样免疫激活型（Basal-like immune-actived，BLISBLIA）共4个亚型[2]。基于抗雌激素治疗手段的广泛使用，ER及PR在乳腺癌中的作用已被深入研究。但另外一个重要的类固醇激素核受体，即雄激素受体（AR）也在不同分子分型乳腺癌中有不同程度的表达，但其在乳腺癌发生发展中所起的作用及机制还未阐明。……