丁苯酞注射液联合胞磷胆碱对急性脑梗死患者脑血流灌注及NIHSS评分的影响

宋元清 高慧 李年春

[摘要] 目的 探讨丁苯酞注射液联合胞磷胆碱对急性脑梗死患者脑血流灌注及NIHSS评分的影响。 方法 选取2018年12月至2019年12月本院急性脑梗死患者60例，分为对照组与观察组，每组各30例。对照组采用灯盏细辛注射液联合胞磷胆碱治疗，观察组采用丁苯酞注射液联合胞磷胆碱治疗，比较两组患者的临床疗效、脑血流灌注及神经功能。 结果 观察组和对照组患者的总有效率（93.33% vs. 83.33%）比较，差异无统计学意义（P>0.05）。观察组患者治疗后较治疗前的CBF、CBV升高幅度均高于对照组，差异均有统计学意义（P<0.05）。观察组患者治疗后较治疗前的NIHSS评分降低幅度高于对照组，差异有统计学意义（P<0.05）。 结论 丁苯酞注射液联合胞磷胆碱对改善患者的血流灌注及神经功能效果好，建议在急性脑梗死治疗中广泛应用。

[关键词] 急性脑梗死;丁苯酞注射液;胞磷胆碱;脑血流灌注;神经功能

[中图分类号] R743.3          [文献标识码] B          [文章编号] 1673-9701（2021）31-0045-03

[Abstract] Objective To explore the effect of butylphthalide injection combined with citicoline on cerebral blood perfusion and NIHSS score in patients with acute cerebral infarction. Methods A total of 60 patients with acute cerebral infarction in our hospital from December 2018 to December 2019 were selected and divided into the control group and the observation group， with 30 cases in each group. The control group was treated with breviscapine injection combined with citicoline， and the observation group was treated with butylphthalide injection combined with citicoline. The clinical efficacy， cerebral blood perfusion， and nerve function were compared between the two groups. Results There was no significant difference in the total effective rate （93.33% vs. 83.33%） between the observation group and the control group（P>0.05）. The increase in CBF and CBV of the observation group after treatment was higher than that of the control group， and the difference was statistically significant（P<0.05）.After treatment，the NIHSS score of the observation group was lower than that of the control group， and the difference was statistically significant（P<0.05）. Conclusion Butylphthalide injection combined with citicoline has a good effect on improving the blood perfusion and nerve function of patients， and it is recommended to be widely used in the treatment of acute cerebral infarction.

[Key words] Acute cerebral infarction; Butylphthalide injection; Citicoline; Cerebral blood perfusion; Nerve function

急性腦梗死在临床较为常见，指血液循环障碍造成局部脑组织缺血、缺氧、坏死，促进梗死灶的形成，从而引发脑功能障碍，中老年是高发人群，病死率、致残率较高，预后差。现阶段，溶栓、抗血小板聚集、对神经进行保护等是临床治疗急性脑梗死过程中通常采用的方法[1]。丁苯酞是一种新型脑保护剂，能够在极大程度上改善缺血区脑灌注，对神经功能损伤进行修护，疗效显著[2]。胞磷胆碱为核苷衍生物，可改善脑梗死患者意识障碍及脑电图情况，具有促进神经功能苏醒及恢复的作用[3]。……