地屈孕酮与硫酸镁联用在先兆早产中的临床应用及妊娠结局分析

尚鑫桐 黄楠 裘雅芬

[摘要] 目的 探討地屈孕酮与硫酸镁联用在先兆早产中的临床疗效及其对妊娠结局的影响。 方法 选取2017年1月至2019年12月我院收治的先兆早产孕妇80例，本研究采用随机数字法将孕妇分为观察组与对照组，每组各40例。对照组静滴硫酸镁注射液进行治疗，观察组静滴硫酸镁注射液联合地屈孕酮进行治疗。比较两组患者的临床治疗效果、妊娠结局、新生儿的结局及不良反应发生情况。 结果 治疗后，观察组总有效率高于对照组，差异有统计学意义（P<0.05）;两组的流产或早产率比较，差异无统计学意义（P>0.05）;观察组足月分娩率及新生儿存活率均明显高于对照组，差异有统计学意义（P<0.05）;观察组的新生儿窒息率及低出生体质量率明显低于对照组，差异有统计学意义（P<0.05）;观察组两组的新生儿Apgar评分明显高于对照组，差异有统计学意义（P<0.05）;两组总不良反应率比较，差异无统计学意义（P>0.05）。 结论 地屈孕酮联合硫酸镁应用于先兆早产孕妇，可有效改善妊娠结局及新生儿结局，具有显著疗效和良好的安全性。

[关键词] 地屈孕酮;硫酸镁;先兆早产;妊娠结局;新生儿结局

[中图分类号] R714.2          [文献标识码] B          [文章编号] 1673-9701（2021）31-0080-04

[Abstract] Objective To explore the clinical efficacy of dydrogesterone combined with magnesium sulfate in the treatment of threatened preterm labor and its effect on pregnancy outcome. Methods A total of 80 pregnant women with threatened preterm labor who were admitted to our hospital from January 2017 to December 2019 were selected. The pregnant women were divided into the observation group and the control group by the random number method， with 40 patients in each group. The control group was treated with intravenous magnesium sulfate injection， and the observation group was treated with intravenous magnesium sulfate injection combined with dydrogesterone.The clinical treatment effect， pregnancy outcome， neonatal outcome and the occurrence of adverse reactions were compared between the two groups. Results After treatment， the overall effective rate in the observation group was higher than that in the control group， with a statistically significant difference （P<0.05）.There was no significant differences were observed in the rates of abortion and preterm birth between the observation group and the control group （P>0.05）. The term delivery rate and neonatal survival rate of the two groups were significantly higher in the observation group than in the control group， with statistically significant differences（P<0.05）.The neonatal asphyxia rate and low birth weight rate of the two groups were compared， and those of the observation group was significantly lower than those of the control group， with statistically significant differences（P<0.05）.The Apgar score of neonates in the observation group was significantly higher than that in the control group， with a statistically significant difference（P<0.05）.Thers was no significant difference was observed in the rate of total adverse reactions between the two groups（P>0.05）. Conclusion Dydrogesterone combined with magnesium sulfate in pregnant women with threatened preterm labor can effectively improve the pregnancy outcome and neonatal outcome， with significant efficacy and good safety.

[Key words] Dydrogesterone; Magnesium sulfate; Threatened premature labor; Pregnancy outcome; Neonatal outcome

早产是指妊娠满28周而不足37周分娩，是影响新生儿出生质量的重要因素之一，可导致新生儿死亡、婴幼儿发育不良[1-2]。先兆早产是早产之前的阶段，若在先兆早产期间采用一定药物治疗以促使孕妇宫缩减缓或停止，可改善子宫内胎儿生长发育环境，达到保胎、预防早产的目的[3]。……