
摘要: 目的 探讨正性音乐联合帕罗西汀治疗脑卒中抑郁(Post-Stroke Depression,PSD)的疗效 。 方法 选取2020年8月至2021年8月成都大学附属医院神经内科和康复科收治的50例PSD患者,采用汉密尔顿抑郁量表( Hamilton Depresion Scale ,HAMD) 评估抑郁状态,中国卒中量表(Chinese Stroke Scale CSS)评估神经功能缺损程度, Barthel指数量表评定日常生活活动能力,将50例PSD患者随机分为对照组与观察组,各25 例,对照组采用口服帕罗西汀片治疗,观察组在采用口服帕罗西汀片基础上联合正性音乐治疗。结果 观察组患者治疗后的HAMD及CSS评分低于对照组(P<0.05), Barthel指数评分高于对照组(P<0.05)。结论 正性音乐联合帕罗西汀治疗PSD临床疗效优于帕罗西汀治疗PSD。
关键词:正性音乐;帕罗西汀片;PSD;疗效观察
【中图分类号】R743.3;R749.4 【文献标识码】A 【文章编号】1673-9026(2021)15--02
【Abstract】Objective Objective to investigate the efficacy of positive music combined with paroxetine in the treatment of stroke depression Methods 50 PSD patients admitted to department of neurology and rehabilitation of affiliated hospital of chengdu university from August 2020 to August 2021 were selected, Hamilton depression scale was used to evaluate depression status,The Chinese stroke scale assessed the degree of neurological impairment, Barthel index scale assesses the ability of daily living activities,fifty PSD patients were randomly divided into control group and observation group,the 25 cases,the control was treated with oral administration of paroxetine tablets,The observation group was treated with oral paroxetine tablets combined with positive music.Results HAMD and CSS scores of patients in the observation group after treatment were lower than those in the control group(P<0.05), Barthel index score was higher than the control group(P<0.05). Conclusion Positive music comblined with paroxetine in the treatment of PSD clinical efficacy is better than that of paroxetine in the treatment of PSD.
【Key words】 positive music ;paroxetine tablet; PSD;clinical observation on
腦卒中是神经系统常见的脑血管意外疾病,表现为突发性意识、语言及运动障碍,严重影响患者的身心健康,据资料统计,首次脑卒中后患者出现抑郁、焦虑达10% ~ 20% ,复发患者中此比例高达50% 以上,对患者的意识及躯体恢复治疗产生重要影响[1],并且抑郁症患者在抑郁症期间会出现频繁自杀和频繁入院治疗[2]。在抗抑郁的治疗研究中,一旦确诊为PSD,治疗首选抗抑郁药SSRIs[3,4],有研究显示SSRIs类抗抑郁药物中,帕罗西汀治疗PSD显效率达到93.1%,而且依从性好[5],同时降低不良反应发生风险[6]。广大临床学者过多关注药物治疗,忽视心理干预手段,音乐疗法[7]可运用音乐特有的生理、心理效应,通过音乐体验,达到消除心理障碍、缓解抑郁情绪 ,本研究选取①春江花月夜、②月光……