来曲唑联合黄体酮治疗多囊卵巢综合征不孕及对卵巢功能的影响

梁原

【摘 要】目的：探讨来曲唑+黄体酮对多囊卵巢综合征不孕的联合疗效，及患者卵巢功能有何改善。方法：视2019年9月至2021年2月在本院求诊的多囊卵巢综合征不孕患者为研究对象，遴选出总82例予以分组。列入观察组的41例接受来曲唑+黄体酮联合用药，列入对照组的41例则接受来曲唑单纯用药。结果：观察组患者E2水平及有效率评测值显著较对照组高（P<0.05），FSH、LH水平显著较对照组低（P<0.05）。结论：来曲唑+黄体酮联合治疗多囊卵巢综合征不孕的效果理想，患者卵巢功能得以改善，具临床价值。

【关键词】多囊卵巢综合征不孕；黄体酮；来曲唑；联合用药；卵巢功能

Letrozole combined with progesterone in the treatment of infertility with polycystic ovary syndrome and its effect on ovarian function

Liang Yuan

Department of Gynecology， YanjiaoErsan Hospital， Sanhe， Sanhe Hebei 065201， China

【Abstract】Objective： To explore the combined effect of letrozole and progesterone on infertility with polycystic ovary syndrome， and how to improve the ovarian function of patients. Methods： A total of 82 patients with infertility with polycystic ovary syndrome who were treated in our hospital from September 2019 to February 2021 were selected as the research object sand divided into groups. The 41 cases included in the observation group received letrozole + progesterone combination， and the 41 cases included in the control group received letrozole alone. Results： The E2 level and effective rate evaluation values of the observation group were significantly higher than those of the control group（P<0.05）， and the levels of FSH and LH were significantly lower than those of the control group（P<0.05）. Conclusion： The combination of letrozole and progesterone is effective in the treatment of infertility with polycystic ovary syndrome，the patient’s ovarian function can be improved and has clinical value.

【Key？Words】Polycystic ovary syndrome infertility； Progesterone； Letrozole； Combination medication； Ovarian function

多囊卵巢綜合征是一种复杂的内分泌代谢疾病，有可能引起排卵异常，导致患者不孕[1]。临床表现还包括月经异常、高雄激素血症，同时可伴有胰岛素抵抗、血脂紊乱等代谢异常，对女性的健康有着长远而广泛的影响，配合长期规范治疗至关重要[2]。目前，药物治疗已取代手术作为该病症的一线治疗方法，于月经周期开始后应用来曲唑进行促排卵治疗，但收效不够理想，且临床胃肠道及疲劳等副作用较多[3]。本研究遴选出82例多囊卵巢综合征不孕患者予以来曲唑+黄体酮联合用药，报道以示下文。

1.1 一般资料

视2019年9月至2021年2月在本院求诊的多囊卵巢综合征不孕患者为研究对象，遴选出总82例予以分组。患者均为女性，对研究知情，同时排除对所用药物有所禁忌者。观察组，年龄23岁～37岁，平均年龄（29.13±2.09）岁，确诊不孕1年～8年，平均时间（3.31±0.35）年。……