吲哚布芬与阿司匹林对颈动脉硬化患者微炎性状态及斑块稳定性的影响研究

熊爱华

【摘要】 目的：研究與观察吲哚布芬与阿司匹林对颈动脉硬化患者微炎性状态及斑块稳定性的影响。方法：选取2018年2月-2019年9月80例颈动脉硬化患者，根据随机数字表法将其分为对照组和试验组，每组40例。对照组采用阿司匹林治疗，试验组采用吲哚布芬。比较两组治疗6、12个月的效果，比较两组治疗前及治疗6、12个月的血清微炎性状态指标（hs-CRP、IL-6、TNF-α）、相关影像学指标（IMT、BI、EI）及斑块稳定性相关血清指标（Hcy、sCD40L、MMP-9）。结果：治疗6、12个月，试验组总有效率均高于对照组，差异均有统计学意义（P<0.05）。治疗前，两组hs-CRP、IL-6、TNF-α、IMT、BI、EI、Hcy、sCD40L、MMP-9比较，差异均无统计学意义（P>0.05）;治疗6、12个月，试验组hs-CRP、IL-6、TNF-α、IMT、BI、EI、Hcy、sCD40L、MMP-9均低于对照组，差异均有统计学意义（P<0.05）。结论：吲哚布芬对颈动脉硬化患者微炎性状态及斑块稳定性的影响优于阿司匹林，在颈动脉硬化患者中的应用价值相对较高。

【关键词】 吲哚布芬 阿司匹林 颈动脉硬化 微炎性状态 斑块稳定性

Study on the Influence of Indobufen and Aspirin for Microinflammatory State and Plaque Stability of Patients with Carotid Atherosclerosis/XIONG Aihua. //Medical Innovation of China， 2021， 18（27）： 025-029

[Abstract] Objective： To study and observe the influence of Indobufen and Aspirin for microinflammatory state and plaque stability of patients with carotid atherosclerosis. Method： A total of 80 patients with carotid atherosclerosis from February 2018 to September 2019 were selected， they were divided into control group and experience group according to the method of random number table， 40 cases in each group. The control group was treated with Aspirin， the experience group was treated with Indobufen. The effects of 6 and 12 months of treatment were compared between two groups， and the serum microinflammatory state （hs-CRP， IL-6， TNF-α）， related imaging indicators （IMT， BI， EI） and plaque stability related serum indicators （Hcy， sCD40L， MMP-9） before and 6 and 12 months of treatment were compared between two groups. Result： 6 and 12 months of treatment， the total effective rate of the experience group were higher than those of the control group， the differences were statistically significant （P<0.05）. Before treatment， there were no significant differences in hs-CRP， IL-6， TNF-α， IMT， BI， EI， Hcy， sCD40L and MMP-9 between two groups （P>0.05）; 6 and 12 months of treatment， hs-CRP， IL-6， TNF-α， IMT， BI， EI， Hcy， sCD40L and MMP-9 of the experience group were lower than those of the control group， the differences were statistically significant （P<0.05）. Conclusion： The influence of Indobufen for microinflammatory state and plaque stability of patients with carotid atherosclerosis are superior than Aspirin， so its application value in the patients with carotid atherosclerosis is relatively higher.

[Key words] Indobufen Aspirin Carotid atherosclerosis Microinflammatory state Plaque stability

First-author’s address： Yichun Second People’s Hospital， Yichun 336000， China

doi：10.3969/j.issn.1674-4985.2021.27.007

颈动脉硬化与多类脑血管疾病的发生密切相关，是临床防控与诊治的重点。临床中与本病相关的研究显示，本类患者除表现出颈动脉硬化斑块等情况，还普遍存在微炎性状态，对血管内皮及功能造成不良影响，同时斑块稳定性的控制也是疗效评估的重点方面[1-2]。临床中采用吲哚布芬与阿司匹林治疗颈动脉硬化的研究均可见，但是其对患者上述微炎性状态及斑块稳定性的影响研究极为匮乏[3-5]。因此，本研究就吲哚布芬与阿司匹林在颈动脉硬化患者微炎性状态及斑块稳定性的影响进行细致探究，以为颈动脉硬化治疗方式的选择提供参考依据，现报道如下。……