小儿定喘口服液辅助治疗小儿支气管肺炎的疗效及其对炎症因子的影响

冯宏达

[摘要] 目的 探讨小儿定喘口服液辅助治疗小儿支气管肺炎的疗效及其对炎症因子的影响。 方法 选取2018年10月至2019年11月我院收治的124例小儿支气管肺炎患儿，按照随机数字表法分为对照组与观察组，每组各62例。对照组采用常规治疗，观察组则在常规治疗基础上应用小儿定喘口服液辅助治疗。观察两组患儿的临床指标、治疗效果及血清炎性因子IL-6、TNF-α的表达。 结果 观察组患儿气喘时间、发热时间、肺部啰音消失时间、住院时间、X线阴影消失时间均明显低于对照组（P<0.05）。观察组患儿治疗总有效率（96.77%）高于对照组（85.48%），差异有统计学意义（P<0.05）。两组患儿治疗前血清IL-6、TNF-α水平比较，差异无统计学意义（P>0.05），治疗后两组患儿血清IL-6、TNF-α均有所下降，但观察组下降水平优于对照组（P<0.05）。 结论 应用小儿定喘口服液辅助治疗小儿支气管肺炎疾病效果显著，能有效改善患者的血清炎症因子水平。

[关键词] 小儿定喘口服液;小儿支气管;白介素-6;肿瘤坏死因子-α

[Abstract] Objective To explore the efficacy of the adjuvant therapy of Pediatric Dingchuan Oral Liquid for children against bronchopneumonia in children and its influence on inflammatory factors. Methods A total of 124 children with bronchopneumonia admitted to and treated in our hospital from October 2018 to November 2019 were selected as the subjects of research. According to the random number table method， they were divided into the control group and the observation group， with 62 children in each group. The control group received routine treatment， while the observation group received the adjuvant therapy of Pediatric Dingchuan Oral Liquid on the basis of routine treatment.The clinical indexes， curative effects and expressions of serum inflammatory factors IL-6 and TNF-α of the two groups were statistically compared. Results The asthma time， fever time， pulmonary rales disappearance time， hospitalization time and X-ray shadow disappearance time of the children in the observation group were significantly shorter than those in the control group（P<0.05）. The total effective rate of treatment（96.77%） of the children in the observation group was higher than that in the control group （85.48%），and the difference was statistically significant（P<0.05）. There was no significant difference in serum IL-6 and TNF-α levels between the two groups before treatment（P>0.05），and after treatment， the serum IL-6 and TNF-α levels of the children in the two groups all decreased， but the decrease level of the observation group was superior to that of the control group（P<0.05）. Conclusion The adjuvant therapy of Pediatric Dingchuan Oral Liquid against the disease of bronchopneumonia in children has significant efficacy. It can effectively ameliorate the level of serum inflammatory factors in patients.

[Key words] Pediatric Dingchuan Oral Liquid; Pediatric bronchus; IL-6; TNF-α

小兒支气管炎是临床常见的儿科呼吸系统疾病，多发于儿童，且不具有季节性，但在气候骤变时易致患儿生病[1-2]，患儿易诱发贫血、营养不良及先天性心脏病等并发症，是严重威胁患儿健康的主要疾病[3-4]。临床治疗小儿支气管炎多采用化痰、抗感染等支持治疗，但治疗效果仍需进一步提高。传统植物药为治疗小儿支气管炎提供了新的途径。小儿定咳口服液由麻黄、葶苈子、苦杏仁、鱼腥草等多种成分提炼浓缩而成，能够清热化痰、宣肺定喘，缓解咳嗽、气喘等由炎症引起的各种呼吸道症状，可能是小儿支气管炎潜在的辅助治疗用药。为进一步提高治疗小儿支气管肺炎的效果，本研究就小儿定咳口服液辅助治疗小儿支气管肺炎疗效及对炎性因子的影响进行探讨，现报道如下。……