通络地龟汤对甲亢患者的疗效及血清NGAL、hs-CRP表达的影响

孟玉娟

【摘要】 目的：探讨通络地龟汤对甲亢患者的疗效及血清中性粒细胞明胶酶相关脂质运载蛋白（neutrophil gelatinasas soeiated lipoealin，NGAL）与超敏C反应蛋白（high-sensitivity C-reactive protein，hs-CRP）表达的影响。方法：选取2018年3月-2020年10月在本院诊治的甲亢患者144例，根据随机信封抽签原则将患者分为中医组与对照組，每组72例。对照组给予甲巯咪唑治疗，中医组在对照组治疗的基础上给予通络地龟汤治疗，两组均治疗3个月，比较两组疗效、治疗前后甲状腺激素含量与甲状腺体积。结果：中医组总有效率为98.6%，高于对照组的88.9%（P<0.05）。治疗后，两组血清FT3与FT4均低于治疗前，且中医组均低于对照组（P<0.05）。治疗后，两组甲状腺体积均小于治疗前，且中医组小于对照组（P<0.05）。治疗后，两组血清NGAL、hs-CRP均低于治疗前，且中医组均低于对照组（P<0.05）。结论：通络地龟汤辅助治疗甲亢能提高效果，促进恢复甲状腺激素的分泌，缩小甲状腺体积，抑制患者血清NGAL、hs-CRP的表达。

【关键词】 通络地龟汤 甲亢 中性粒细胞明胶酶相关脂质运载蛋白 超敏C反应蛋白 甲状腺体积

Curative Effect of Tongluo Digui Decoction on Patients with Hyperthyroidism and Its Influence on Serum NGAL and hs-CRP Expression/MENG Yujuan. //Medical Innovation of China， 2021， 18（32）： 0-083

[Abstract] Objective： To explore the curative effect of Tongluo Digui Decoction on patients with hyperthyroidism and its influence on the serum neutrophil gelatinasas soeiated lipoealin （NGAL） and high-sensitivity C-reactive protein （hs-CRP）. Method： A total of 144 patients with hyperthyroidism who diagnosed and treated in our hospital from March 2018 to October 2020 were selected， according to the principle of random envelope drawing， the patients were divided into the traditional Chinese medicine （TCM） group and the control group， 72 cases in each group. The control group was treated with Thiamazole， and the TCM group was treated with Tongluo Digui Decoction on the basis of the control group， two groups were treated for 3 months. The curative effect， thyroid hormone content and thyroid volume before and after treatment were compared between the two groups. Result： The total effective rate in the TCM group was 98.6%， which was higher than 88.9% in the control group （P<0.05）. After treatment， the serum FT3 and FT4 of two groups were lower than those before treatment， and the TCM group were lower than those of the control group （P<0.05）. After treatment， the thyroid volume in two groups were lower than those before treatment， and the TCM group was lower than that in the control group （P<0.05）. After treatment， the serum NGAL and hs-CRP of two groups were lower than those before treatment， and the TCM group were lower than those of the control group （P<0.05）. Conclusion： Tongluo Digui Decoction adjuvant treatment of hyperthyroidism can inhibit the expression of serum NGAL and hs-CRP in patients， promote the restoration of thyroid hormone secretion， improve the therapeutic effect， and reduce the thyroid volume.

[Key words] Tongluo Digui Decoction Hyperthyroidism Neutrophil gelatinasas soeiated lipoealin High-sensitivity C-reactive protein Thyroid volume

First-author’s address： Shenyang Hospital of Traditional Chinese Medicine， Shenyang 110004， China

doi：10.3969/j.issn.1674-4985.2021.32.020

甲状腺功能亢进症简称甲亢，是指由多种原因导致甲状腺激素分泌过多、引起甲状腺功能增高所致的一种常见的代谢性内分泌疾病[1-2]。甲亢的发病机制尚未明确，其为遗传、环境、免疫等多种因素共同作用的结果，在临床上主要表现为急躁易怒，中医辨证为肝火偏亢[3]。当前西医治疗甲亢多采用甲巯咪唑，其能诱导甲状腺内浸润的T淋巴细胞凋亡，抑制甲状腺细胞自身抗原呈递，能清除活性氧，从而达到有效的治疗效果[4]。……