健脾止泻汤治疗溃疡性结肠炎的临床效果

杨彬

【摘要】 目的：探讨健脾止泻汤治疗溃疡性结肠炎的临床效果。方法：选取2016年6月-2019年5月本院收治的溃疡性结肠炎患者75例，根据随机数字表法分为对照组（n=37）与研究组（n=38）。对照组应用常规西药治疗，研究组应用健脾止泻汤治疗。比较两组治疗效果及治疗前后血清炎性因子水平、免疫功能指标及凝血功能指标。结果：研究组总有效率高于对照组（P<0.05）。两组治疗前血清炎性因子水平、免疫功能指标及凝血功能指标比较，差异均无统计学意义（P>0.05）;研究组治疗后血清IL-1、TNF-α、CRP及凝血功能指标均低于对照组，免疫功能指标均优于对照组，差异均有统计学意义（P<0.05）。结论：溃疡性结肠炎应用健脾止泻汤治疗效果显著，可有效降低机体血清炎性因子，同时还能有效增强免疫功能，改善凝血功能，从而加快患者康复，值得在临床上进一步推广应用。

【关键词】 溃疡性结肠炎 健脾止泻汤 IL-1 TNF-α CRP

Clinical Effect of Jianpi Zhixie Decoction in the Treatment of Ulcerative Colitis/YANG Bin. //Medical Innovation of China， 2021， 18（32）： 0-095

[Abstract] Objective： To investigate the clinical effect of Jianpi Zhixie Decoction in the treatment of ulcerative colitis. Method： A total of 75 patients with ulcerative colitis admitted to our hospital from June 2016 to May 2019 were selected and divided into the control group （n=37） and the study group （n=38） according to random number table method. The control group was treated with conventional Western medicine， and the research group was treated with Jianpi Zhixie Decoction. The therapeutic effect， serum inflammatory factors （IL-1， TNF-α， CRP）， immune function indexes （CD3+， CD4+） and coagulation function indexes （FIB， PLT） were compared between two groups. Result： The total effective rate of study group was higher than that of control group （P<0.05）. There were no significant differences in serum inflammatory factor levels， immune function indexes and coagulation function indexes between two groups before treatment （P>0.05）; the levels of IL-1， TNF-α， CRP and coagulation function indexes in the study group were lower than those in the control group， the immune function indexes of the study group were better than those of the control group， the differences were statistically significant （P<0.05）. Conclusion： The therapeutic effect of Jianpi Zhixie Decoction on ulcerative colitis is remarkable， it can effectively reduce the serum levels of inflammatory cytokines， enhance the immune function， improve the function of blood coagulation， so as to speed up the recovery time of patients， it is worthy of further popularization and application in clinic.

[Key words] Ulcerative colitis Jianpi Zhixie Decoction IL-1 TNF-α CRP

First-author’s address： Jiamusi Anorectal Hospital， Jiamusi 154002， China

doi：10.3969/j.issn.1674-4985.2021.32.023

在認知的炎性疾病中，溃疡性结肠炎是其中一种较为常见且多发的慢性反应性疾病，具有病程长、非特异性、易反复发作的特点[1]。目前，临床对溃疡性结肠炎的发病机制尚不明确，有医学专家认为遗传、感染、环境、免疫等原因，会影响该疾病的发生、发展[2]。如果溃疡性结肠炎没有得到及时有效的治疗，就会连累整个结肠，进而大出血，诱发中毒性巨结肠，甚至会发生癌变，严重危害患者的健康安全[3-5]。现阶段，临床仍没有治疗溃疡性结肠炎的特效药，主要应用肾上腺皮质激素、免疫抑制剂、水杨酸类药物进行治疗，但疗效十分不理想，预后较差[6-8]。……