依达拉奉联合银杏达莫治疗糖尿病并发急性脑梗死的效果及对神经功能与预后的影响

李波 彭琛 杨水斌 张婷 李焕生

【摘要】 目的：探究依達拉奉联合银杏达莫治疗糖尿病并发急性脑梗死的效果及对神经功能与预后的影响。方法：选取2018年9月-2019年9月本院收治的100例糖尿病并发急性脑梗死患者作为研究对象，采用非随机对照试验设计将患者分为对照组（n=49）与观察组（n=51）。对照组给予常规治疗与依达拉奉，观察组在对照组基础上给予银杏达莫。比较两组治疗14 d后的疗效，比较两组治疗前、治疗14 d后神经功能、椎基底动脉血流速度，比较两组治疗期间不良反应发生情况。结果：治疗14 d后，观察组总有效率高于对照组（P<0.05）。治疗14 d后，两组美国国立卫生研究院卒中量表（NIHSS）评分均较治疗前下降，且观察组低于对照组，差异均有统计学意义（P<0.05）。治疗14 d后，两组左侧椎动脉血流速度（LVA）、右侧椎动脉血流速度（RVA）、基底动脉血流速度（BA）水平均较治疗前升高，且观察组均高于对照组（P<0.05）。两组治疗期间各不良反应发生率比较，差异均无统计学意义（P>0.05）。结论：依达拉奉联合银杏达莫治疗糖尿病并发急性脑梗死可有效提升临床效果，并改善神经功能及脑部血流状况，且使用安全性较好。

【关键词】 依达拉奉 银杏达莫 糖尿病 急性脑梗死 神经功能

Effect of Edaravone Combined with Ginkgo-damole on Diabetes Mellitus Complicated with Acute Cerebral Infarction and Its Effect on Nerve Function and Prognosis/LI Bo， PENG Chen， YANG Shuibin， ZHANG Ting， LI Huansheng. //Medical Innovation of China， 2021， 18（28）： 0-044

[Abstract] Objective： To explore the effect of Edaravone combined with Ginkgo-damole on diabetes mellitus complicated with acute cerebral infarction and its effect on nerve function and prognosis. Method： A total of 100 patients diabetes mellitus complicated with acute cerebral infarction who were admitted to our hospital between September 2018 and September 2019 were selected as the research subjects， and they were divided into the control group （n=49） and the observation group （n=51） by non-randomized controlled trial design. Patients in the control group were given basic treatment and Edaravone， and patients in the observation group were combined with Ginkgo-damole on the basis of control group. The efficacy after 14 d of treatment was compared between two groups， and the neurological function and blood flow velocities of vertebrobasilar arteries were compared between two groups before treatment and after 14 d of treatment. The adverse reactions were compared between two groups during treatment. Result： After 14 d of treatment， the total effective rate in the observation group was higher than that in the control group （P<0.05）. After 14 d of treatment， the national institutes of health stroke scale （NIHSS） scores of two groups were lower than those before treatment， and the observation group was lower than that in the control group during the same period （P<0.05）. After 14 d of treatment， the levels of left vertebral artery blood flow velocity （LVA）， right vertebral artery blood flow velocity （RVA）， basilar artery blood flow velocity （BA） of two groups were higher than those before treatment， and the levels in the observation group were higher than those in the control group （P<0.05）. There were no significant differences in the occurrence of adverse reactions between two groups during treatment （P>0.05）. Conclusion： Edaravone combined with Ginkgo-damole has a significant efficacy on patients with diabetes mellitus complicated with acute cerebral infarction， it can effectively promote the recovery of neurological function and blood flow， and it has good safety during application.

[Key words] Edaravone Ginkgo-damole Diabetes mellitus Acute cerebral infarction Neurological function

First-author’s address： General Hospital of Pingxiang Mining Group Co.， Ltd.， Pingxiang 337000， China

doi：10.3969/j.issn.1674-4985.2021.28.010

糖尿病是我国发病率较高的疾病，多集中于中老年人群，对患者生活、健康均造成严重不良影响[1-2]。糖尿病患者大多受胰岛素分泌异常影响，高血糖可影响全身组织器官的代谢情况，对中枢神经系统亦存在一定损害，且糖尿病患者血液黏稠度水平较高，导致脑梗死发病率较高[3-4]。……