阿加曲班联合血塞通治疗脑梗死患者的效果及对脑血流动力学的影响

付丽洁

【摘要】 目的：探讨阿加曲班联合血塞通治疗脑梗死患者的效果及对脑血流动力学的影响。方法：选取2019年1月-2020年5月本院收治的94例脑梗死患者，根据治疗方式的不同将其分成对照组和研究组，每组47例。对照组接受单一血塞通药物治疗，研究组接受阿加曲班联合血塞通治疗。比较两组治疗效果、治疗前后的神经功能缺损评分、日常生活能力评分和血流动力学指标。结果：研究组总有效率高于对照组，差异有统计学意义（P<0.05）。治疗前，两组神经功能缺损、日常生活能力评分比较，差异均无统计学意义（P>0.05）;治疗后，研究组神經功能缺损评分低于对照组，日常生活能力评分高于对照组，差异均有统计学意义（P<0.05）。治疗前，两组凝血酶原时间、血浆黏度、纤维蛋白原、全血高切血浆黏度、全血低切血浆黏度比较，差异均无统计学意义（P>0.05）;治疗后，研究组凝血酶原时间长于对照组，血浆黏度、纤维蛋白原、全血高切血浆黏度、全血低切血浆黏度均低于对照组，差异均有统计学意义（P<0.05）。结论：在脑梗死患者的临床治疗中应用阿加曲班联合血塞通可改善患者的神经功能和日常生活能力，改善血流动力学指标，提高临床治疗效果，值得推广应用。

【关键词】 脑梗死 阿加曲班 血塞通 脑血流动力学

Effect of Argatroban Combined with Xuesaitong on Cerebral Hemodynamics in Patients with Cerebral Infarction/FU Lijie. //Medical Innovation of China， 2021， 18（28）： -142

[Abstract] Objective： To explore the efficacy of Argatroban combined with Xuesaitong in the treatment of patients with cerebral infarction and its influence on cerebral hemodynamics. Method： A total of 94 patients with cerebral infarction admitted to our hospital from January 2019 to May 2020 were selected， they were divided into control group and study group according to different treatment methods， 47 cases in each group. The control group received single Xuesaitong treatment， the study group received Argatroban combined with Xuesaitong treatment. The treatment effect， neurological deficit score， daily living ability score and hemodynamic indexes before and after treatment were compared between two groups. Result： The total effective rate of the study group was higher than that of the control group， the difference was statistically significant （P<0.05）. Before treatment， there were no significant differences in neurological deficit scores and daily living ability scores between two groups （P>0.05）; after treatment， the neurological deficit score of the study group was lower than that of the control group， and the daily living ability score of the study group was higher than that of the control group， the differences were statistically significant （P<0.05）. Before treatment， there were no significant differences in activated partial thromboplastin time， plasma viscosity， fibrinogen， plasma viscosity of whole blood high-cut plasma viscosity and whole blood low-cut plasma viscosity between two groups （P>0.05）; after treatment， activated partial thromboplastin time of the study group was longer than that of the control group， and plasma viscosity， fibrinogen， whole blood high-cut plasma viscosity and whole blood low-cut plasma viscosity of the study group were lower than those of the control group， the differences were statistically significant （P<0.05）. Conclusion： Application of Argatroban combined with Xuesaitong in the clinical treatment of patients with cerebral infarction can improve the neurological function and daily living ability of patients， improve the hemodynamic indexes， improve the clinical treatment effect， which is worthy of popularization and application.

[Key words] Cerebral infarction Argatroban Xuesaitong Cerebral hemodynamics

First-author’s address： Liaoyang Zhongxin Xincheng Hospital， Liaoyang 111000， China

doi：10.3969/j.issn.1674-4985.2021.28.034

脑梗死属于临床上比较常见的一种脑血管疾病，高发群体为中老年人。脑梗死具有高发病率、进展快和病因复杂等疾病特点[1]。脑梗死的发病机制为：机体内脑动脉狭窄、阻塞等现象，促使脑组织的供血、供氧需求无法得到满足，最终引发脑组织坏死[2]。……