右佐匹克隆治疗失眠症的疗效及对患者甲状腺激素水平的影响

刘颖　朱永

[摘要] 目的 探讨右佐匹克隆治疗失眠症的疗效及对患者甲状腺激素水平的影响。 方法 选取2019年1—12月在我院诊断治疗的失眠症患者60例为研究对象，随机分为观察组与对照组，每组各30例。观察组采用右佐匹克隆治疗，对照组采用艾司唑仑治疗，比较两组治疗前后PSQI、T3、T4、TSH水平及临床疗效。 结果 治疗后两组PSQI得分均低于治疗前，差异有统计学意义（P<0.05）;治疗后观察组PSQI得分显著低于对照组，差异有统计学意义（P<0.05）。治疗后两组T3、T4均较治疗前显著下降，差异有统计学意义（P<0.05）;治疗后观察组T3、T4均显著低于对照组，差异有统计学意义（P<0.05）;两组治疗前后TSH比较，差异均无统计学意义（P>0.05）。观察组痊愈率为50.00%，高于对照组的16.67%，差异有统计学意义（P<0.05）。观察组总有效率为96.67%，高于对照组的83.33%，差异有统计学意义（P<0.05）。 结论 右佐匹克隆治疗失眠症具有较好的临床疗效，并且可降低甲状腺激素水平，有利于病情控制。

[关键词] 右佐匹克隆;失眠症;甲状腺激素;三碘甲腺原氨酸;甲状腺素;促甲状腺激素

[中图分类号] R749          [文献标識码] B          [文章编号] 1673-9701（2021）04-0111-03

Efficacy of dexzopiclone in the treatment of insomnia and its effects on patients′ thyroid hormone levels

LIU Ying1   ZHU Yong2

1.Inpatient Pharmacy， Jiamusi Charity Mental Hospital in Heilongjiang Province， Jiamusi   154002， China; 2.No.6 Ward， Jiamusi Charity Mental Hospital in Heilongjiang Province， Jiamusi   154002， China

[Abstract] Objective To investigate the efficacy of dexzopiclone in the treatment of insomnia and its effects on the level of patients′ thyroid hormones. Methods A total of 60 patients with insomnia who were diagnosed and treated in our hospital from January to December 2019 were selected as the study subjects， and were randomly divided into an observation group and a control group， with 30 cases in each group. The observation group was given dexzopiclone for treatment， and the control group was given estazolam for treatment. The PSQI， T3， T4， TSH levels and clinical efficacy were compared between the two groups before and after treatment. Results The PSQI scores in both groups after treatment were lower than those before treatment， and the difference was statistically significant（P<0.05）; after treatment， the PSQI score in the observation group was significantly lower than that in the control group， and the difference was statistically significant（P<0.05）. After treatment， T3 and T4 in both groups were significantly lower than those before treatment， and the differences were statistically significant（P<0.05）; after treatment， T3 and T4 in the observation group were significantly lower than those in the control group， and the differences were statistically significant（P<0.05）; The differences of TSH in the two groups before and after treatment were not statistically significant（P>0.05）. The recovery rate in the observation group was 50.00%， which was higher than that 16.67% in the control group， the difference was statistically significant（P<0.05）. The total effective rate in the observation group was 96.67%， which was higher than that of 83.33% in the control group. However， the difference was statistically significant（P<0.05）. Conclusion Dexzopiclone has a favorable clinical effect in the treatment of insomnia， and can reduce the level of thyroid hormones， which is beneficial to the control of disease conditions.

[Key words] Dexzopiclone; Insomnia; Thyroid hormones; Triiodothyronine; Thyroxine; Thyroid stimulating hormone

失眠症是导致睡眠时间减少、睡眠质量下降，不能满足个体生理需要的一种疾病，明显影响患者的日间社会功能或生活质量。我国有失眠问题的人群比例较高，而车祸、工伤事故等均在一定程度上与睡眠不足有关[1]。右佐匹克隆是一种非苯二氮[艹卓]类催眠药，其催眠机制还不十分明确，目前认为其作用与苯二氮[艹卓]受体偶联的GABA受体复合物有关。有研究显示，失眠可导致甲状腺激素紊乱，甲状腺激素紊乱会加重失眠症状，而改善睡眠状况可改善甲状腺激素紊乱的情况[2]。本文分析右佐匹克隆治疗失眠症的疗效及对患者甲状腺激素水平的影响，以期为临床治疗提供参考，现报道如下。

1 资料与方法

1.1 一般资料

选择2019年1—12月在我院诊断治疗的失眠症患者60例为研究对象，其中男23例，女37例;年龄21～68岁，平均（47.90±10.30）岁。随机分为观察组和对照组，每组各30例。……