康复新液对胃溃疡患者胃黏膜及氧化损伤的改善作用观察

关慧龙

【摘要】 目的：研究康復新液在胃溃疡患者治疗中的效果以及对胃黏膜及氧化损伤的改善作用。方法：选取2018年1月-2019年12月本院收治的96例胃溃疡患者为研究对象，将其按照随机数字表法分为观察组（康复新液+常规治疗）和对照组（常规治疗），各48例，连续治疗4周。观察两组治疗效果、胃黏膜愈合情况、安全性及9个月内的复发情况，比较两组治疗前后氧化损伤指标血清丙二醛（MDA）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）以及基质金属蛋白酶-9（MMP-9）、胃黏膜组织前列腺素E2（PGE2）水平。结果：观察组总有效率为97.92%，明显高于对照组的83.33%，差异有统计学意义（P<0.05）。观察组胃黏膜完全愈合率高于对照组，差异有统计学意义（P<0.05）。治疗后，观察组血清MDA、MMP-9均低于对照组、SOD、GSH-Px、胃黏膜PGE2均高于对照组，差异均有统计学意义（P<0.05）。两组不良事件发生情况比较，差异无统计学意义（P>0.05）。治疗后9个月内，观察组的复发率为4.17%，低于对照组的18.75%（P<0.05）。结论：康复新液在治疗胃溃疡患者的过程中效果较好，对胃黏膜以及氧化损伤可起到较好的改善效果，且安全性较好，复发率较低，值得临床应用。

【关键词】 康复新液 胃溃疡 胃黏膜 氧化损伤

[Abstract] Objective： To study the effect of Kangfuxin Liquid in the treatment of gastric ulcer and the improvement of gastric mucosa and oxidative damage in patients with gastric ulcer. Method： A total of 96 patients with gastric ulcer treated in our hospital from January 2018 to December 2019 were selected as the research objects， according to the random number table method， they were divided into the observation group （Kangfuxin Liquid+conventional treatment） and the control group （conventional treatment）， 48 cases in each group. The patients were treated continuously for 4 weeks. The therapeutic effect， healing of gastric mucosa， safety and recurrence within 9 months were observed， the levels of serum malondialdehyde （MDA）， superoxide dismutase （SOD）， glutathione peroxidase （GSH-Px）， matrix metalloproteinase-9 （MMP-9） and prostaglandin E2 （PGE2） in gastric mucosa were compared between two groups before and after treatment. Result： The total effective rate of the observation group was 97.92%， which was significantly higher than 83.33% of the control group， the difference was statistically significant （P<0.05）. The rate of gastric mucosa complete healing in observation group was higher than that in control group， the difference was statistically significant （P<0.05）. After treatment， serum MDA and MMP-9 in observation group were lower than those in control group， SOD， GSH-Px and gastric mucosa PGE2 in observation group were higher than those in control group， the difference were statistical significance （P<0.05）. There was no significant difference in the incidence of adverse events between two groups （P>0.05）. At 9 months after treatment， the recurrence rate of observation group was 4.17%， which was lower than 18.75% of control group （P<0.05）. Conclusion： Kangfuxin Liquid has a good effect in the treatment of gastric ulcer patients， which can improve the gastric mucosa and oxidative damage， has good safety and low recurrence rate， which is worthy of clinical application.

[Key words] Kangfuxin Liquid Gastric ulcer Gastric mucosa Oxidative damage

First-authors address： Fengcheng Hospital of Traditional Chinese Medicine， Fengcheng 118100， China

doi：10.3969/j.issn.1674-4985.2021.09.009

胃溃疡是临床上较为常见的一种消化性溃疡，主要表现为周期性发作的上腹疼痛、泛酸、呕吐等，常常诱发消化道出血甚至穿孔等严重并发症，病灶主要侵及黏膜全层，甚至可超过黏膜肌层或者更深，具有一定程度的癌变风险[1-3]。目前临床针对胃溃疡的治疗主要采用四联或三联疗法，但修复溃疡的胃黏膜过程较为复杂，是由多细胞及因子共同参与修复治疗的过程，其且随着耐药性的增加以及幽门螺杆菌根除率的下降，导致其复发率较高[4-6]。近年来有研究发现，康复新液具有养阴生肌、疏通血脉的功效，对于促进溃疡创面愈合的效果较好，但对于胃溃疡患者的研究相对较少，尤其是对胃溃疡患者胃黏膜及氧化损伤的改善作用[5-7]。……