循环血miR指标与急性脑梗死患者神经损伤程度及炎性反应的关系探究

凌孟晖 张文敏 张映红

【摘要】 目的：探究循環血miR指标与急性脑梗死患者神经损伤程度及炎性反应的关系。方法：选取2018年5月-2019年4月本院收治的90例急性脑梗死患者作为观察组，同时期的90例体检健康者为对照组。检测与比较两组循环血miR指标（miR-181c、miR-21及miR-210）、神经损伤程度相关指标（血清NSE、S100B及Lp-PLA2）及炎性反应指标（血清IL-6、IL-8及TNF-α），然后比较观察组中不同NIHSS评分结果患者的上述指标，采用Pearson相关性分析循环血miR指标与血清神经损伤程度相关指标及炎性反应指标的关系。结果：观察组循环血miR指标、血清神经损伤程度相关指标及炎性反应指标均显著高于对照组，且观察组中不同NIHSS评分结果患者上述指标比较，差异均有统计学意义（P<0.05）。Pearson相关性分析显示，循环血miR指标与血清神经损伤程度相关指标及炎性反应指标均呈正相关（P<0.05）。结论：循环血miR指标与急性脑梗死患者神经损伤程度及炎性反应有密切的关系，应加强对上述方面的检测与干预。

【关键词】 急性脑梗死 循环血miR指标 神经损伤程度 炎性反应

[Abstract] Objective： To investigate the relationship between circulating blood miR indexes and nerve injury degree， inflammatory reaction indexes of patients with acute cerebral infarction. Method： A total of 90 patients with acute cerebral infarction in our hospital from May 2018 to April 2019 were chosen as the observation group， 90 healthy persons with physical examination at the same time were chosen as the control group. Then the circulating blood miR indexes （miR-181c， miR-21 and miR-210）， nerve injury degree related indexes （serum NSE S100B and Lp-PLA2） and inflammatory reaction indexes （serum IL-6， IL-8 and TNF-α） of two groups were compared， and those indexes of the observation group with different NIHSS scores patients were compared， then the relationship between circulating blood miR indexes and serum nerve injury degree related indexes， inflammatory reaction indexes were analyzed with Pearson correlation analysis. Result： The circulating blood miR indexes， serum nerve injury degree related indexes and inflammatory reaction indexes of the observation group were significantly higher than those of the control group， and those indexes of the observation group with different NIHSS scores patients were compared， there were statistically significant differences （P<0.05）. Pearson correlation analysis showed the circulating blood miR indexes were all positively correlated with serum nerve injury degree related indexes and inflammatory reaction indexes （P<0.05）. Conclusion： The relationship between circulating blood miR indexes and nerve injury degree， inflammatory reaction indexes of patients with acute cerebral infarction are close， and those items should be paid to more detection and intervention.

[Key words] Acute cerebral infarction Circulating blood miR indexes Nerve injury degree Inflammatory reaction

First-authors address： Guangzhou Panyu Traditional Chinese Medicine Hospital， Guangzhou 511400， China

doi：10.3969/j.issn.1674-4985.2021.09.039

急性脑梗死在我国的发病率呈现持续大幅度升高的趋势，与本病相关的研究中，神经损伤与炎性反应状态变化均是重点，研究普遍认为，上述方面可直接或间接反映疾病的严重程度及预后情况等[1-2]。近年来，临床中关于miR指标在急性脑梗死患者中的表达变化研究不断增多，较多研究认为其可在一定程度上反映患者机体的受损及预后情况[3-4]。但临床中关于循环血miR指标与血清神经损伤程度及炎性反应状态的关系探究极为匮乏。鉴于上述情况，本研究就循环血miR指标与急性脑梗死患者神经损伤程度及炎性反应的关系进行探究，现报道如下。

1 资料与方法

1.1 一般资料 选取2018年5月-2019年4月本院收治的90例急性脑梗死患者作为观察组，同时期90例体检健康者作为对照组。……