复方枸橼酸阿尔维林治疗慢性非萎缩性胃炎的安全性及有效性分析

何璠　　郑伟伟　　曾耀明

[摘要] 目的 探讨复方枸缘酸阿尔维林治疗慢性非萎缩性胃炎的安全性及有效性。 方法 从我院2019年1月至2020年1月期间收治的罹患慢性非萎缩性胃炎患者中选取110例作为研究对象，随机分对照组和观察组，每组各55例，对照组予枸橼酸莫沙必利胶囊治疗，观察组予复方枸橼酸阿尔维林胶囊治疗。对比分析两组患者治疗前后各症状积分及总积分、治疗后各症状疗效及不良反应发生率。 结果 治疗前，两组患者各症状积分及总积分比较，差异无统计学意义（P>0.05），治疗后，观察组治疗后总积分为（4.64±0.97）分，对照组为（8.73±1.24）分，差异有统计学意义（P<0.05）。临床治疗期间，观察组1例患者发生不良反应，发生率为1.82%，对照组2例患者发生不良反应，发生率为3.64%，差异无统计学意义（P>0.05）。 结论 对慢性非萎缩性胃炎患者予以复方枸橼酸阿尔维林治疗，疗效显著，可有效改善患者临床症状，降低不良反应，安全性较高，具有十分重要的研究意义。

[关键词] 慢性非萎缩性胃炎;复方枸橼酸阿尔维林;症状积分;不良反应

[中图分類号] R573.3          [文献标识码] B          [文章编号] 1673-9701（2021）12-0047-04

Analysis on safety and efficiency of alverine citrate compound in treatment of chronic non atrophic gastritis

HE Fan   ZHENG Weiwei   ZENG Yaoming

Department of Gastroenterology， the Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine， Wenzhou Hospital of Traditional Chinese Medicine， Wenzhou   325000， China

[Abstract] Objective To discuss the safety and efficiency of alverine citrate compound in the treatment of chronic non-atrophic gastritis（CNAG）. Methods A total of 110 patients with CNAG admitted to our hospital from January 2019 to January 2020 were selected as study objects， and randomly divided into a control group and an observation group， with 55 patients in each group. The control group was treated with Mosapride citrate capsules， while the observation group was treated with compound alverine citrate capsules. The scores of each symptom and total scores before and after treatment， the therapeutic effects of each symptom after treatment and the incidences of adverse reactions of the two groups were compared and analyzed. Results Before treatment， the scores of each symptom and the total scores in the two groups were not statistically different after evaluation （P>0.05）. After treatment， the total score was （4.64±0.97） points in the observation group and （8.73±1.24） points in the control group， and the difference was statistically significant （P<0.05）. During the clinical treatment， adverse reactions were observed in 1 patient in the observation group， with an incidence of 1.82%， and in 2 patients in the control group， with an incidence of 3.64%， with no statistically significant difference （P>0.05）. Conclusion The treatment of CNAG with compound alverine citrate has a significant therapeutic effect. It can effectively relieve the clinical symptoms of patients and reduce adverse reactions， and has high safety， which is of great research significance.

[Key words] Chronic non-atrophic gastritis; Alverine citrate compound; Symptom score; Adverse reaction

慢性非萎缩性胃炎是指在胃黏膜层，以淋巴细胞和浆细胞浸润为主，不伴有胃黏膜萎缩性改变的一种慢性炎症，属于慢性胃炎的一种[1]。据中华医学会消化内镜学分会的调查显示，在慢性胃炎的各种类型中，慢性非萎缩性胃炎的发病率最高，可达59.3%[2]。本病具有发病率高，缠绵难愈的特点，且在临床上没有其特异性的症状，主要表现为上腹部隐痛、泛酸、腹胀、食欲不振等，症状表现较轻微，甚至有部分患者无明显的临床症状，只能通过胃镜检查发现。多数……