脂肪干细胞胶（SVF-gel）填充矫治面部凹陷的疗效探讨

张山 王镜涵 白欣冉 曹哲 梁晓琴

[摘要]目的：探讨脂肪干细胞胶（SVF-gel）填充矫治面部凹陷的临床疗效。方法：选取医院拟实施自体脂肪移植治疗的面部凹陷患者50例，采用完全随机方法分为观察组和对照组，每组25例。分别注射SVF-gel和Coleman脂肪治疗面部凹陷，术后随访，对比两组术后肿胀时间、二次填充率及患者满意度情况。结果：术后观察组面部肿胀时间（8.64±1.18）d明显短于对照组（10.26±1.12）d，且术后二次填充率显著低于对照组，差异具有统计学意义（P<0.05）。观察组患者满意度（96.0%）高于对照组（88.0%），但组间比较差异无统计学意义（P>0.05）。结论：与Coleman脂肪移植比较，SVF-gel填充治疗面部凹陷，术后肿胀时间短、满意度高、治疗效果较好。

[关键词]面部凹陷;脂肪干细胞胶移植;Coleman脂肪;二次填充率;满意度

[中图分类号]R622    [文献标志码]A    [文章编号]1008-6455（2021）05-0032-03

Clinical Application of SVF-gel Transplant in the Treatment of Facial Depression

ZHANG Shan，WANG Jing-han，BAI Xin-ran，CAO Zhe，LIANG Xiao-qin

（Plastic Surgery Institute of Weifang Medical College，Weifang 261000，Shandong，China）

Abstract： Objective  To investigate the clinical efficacy of SVF-gel in the treatment of facial depression. Methods  50 patients with facial depression were selected from the hospital for autologous fat transplantation， and were divided into the observation group and the control group with 25 patients in each group. SVF-gel and Coleman fat were injected to treat facial depression respectively. Patients were followed up after surgery， and the swelling time， secondary filling rate and patient satisfaction after treatment were compared between the two groups. Results  After treatment， the facial swelling time in the observation group was （8.64±1.18）d， which was significantly shorter than that in the control group （10.26±1.12）d， the difference was statistically significant （P<0.05）. Postoperative secondary filling rate was lower than that of the control group （P>0.05）. Patients' satisfaction in the observation group （96.0%） was higher than that in the control group （88.0%），but there was no significant difference between the two groups（P>0.05）. Conclusion  Compared with Coleman fat transplantation， SVF-gel transplantation in the treatment of facial depression has shorter postoperative swelling time and better therapeutic effect.

Key words： facial depression; SVF-gel transplantation; Coleman fat; secondary filling rate; satisfaction

面部凹陷是由于皮下脂肪、面部皮肤松弛、分布不均匀、萎缩而导致，发生后会使面容苍老、憔悴，对美观造成严重影响。自体组织移植填充、人工合成材料填充和生物材料填充是临床主要使用的面部凹陷整复方法[1]。随着脂肪组织填充技术的发展，脂肪填充在面部凹陷治疗中发挥着越来越重要的作用。但因移植后远期存活率的不稳定导致患者满意度不高，限制了脂肪移植更广泛的应用[2]。降低注射移植后的二次填充率，保持移植組织的体积是治疗面部凹陷的关键。临床发现，通过纯物理方法从脂肪组织中获取的富含脂肪干细胞群的胶状浓缩物（SVF-gel），与传统的脂肪移植相比在脂肪的保留率方面具有显著优势[3]。本次研究选取医院拟实施自体脂肪移植治疗的面部凹陷患者50例，探讨了SVF-gel填充的临床效果，现报道如下。