舒芬太尼复合丙泊酚用于尘肺患者大容量肺泡灌洗术的研究

熊江琴 范励侦 黎秋焱 王玉 罗江波 苏盈笑 邓新洪

【摘要】 目的：探討舒芬太尼复合丙泊酚用于尘肺患者大容量肺泡灌洗术的效果。方法：选取江西省胸科医院2018年1月-2020年6月收治的100例尘肺患者，均采用大容量肺泡灌洗术治疗，按照随机数字表法将患者分成观察组（n=50）和对照组（n=50）。对照组采用瑞芬太尼复合丙泊酚静脉麻醉，观察组采用舒芬太尼复合丙泊酚静脉麻醉。比较两组收缩压、心率、血氧饱和度及苏醒时间、自主呼吸恢复时间、拔管时间、不良反应发生情况、躁动程度。结果：手术过程中，观察组平均动脉压、心率均高于对照组，差异均有统计学意义（P<0.05）;观察组血氧饱和度与对照组比较，差异无统计学意义（P>0.05）;观察组苏醒时间、自主呼吸恢复时间、拔管时间均长于对照组，差异均有统计学意义（P<0.05）;观察组不良反应发生率为4.0%，低于对照组的18.0%，差异有统计学意义（P<0.05）;观察组清醒拔管时SAS评分低于对照组，差异有统计学意义（P<0.05）。结论：舒芬太尼复合丙泊酚用于尘肺患者大容量肺泡灌洗术具有明显效果，镇静效果佳，可保持良好生命体征，减少躁动，安全性高。

【关键词】 舒芬太尼 丙泊酚 尘肺 大容量肺泡灌洗术

Study of Sufentanil Combined with Propofol in Patients with Pneumoconiosis Undergoing Large Volume Alveolar Lavage/XIONG Jiangqin， FAN Lizhen， LI Qiuyan， WANG Yu， LUO Jiangbo， SU Yingxiao， DENG Xinhong. //Medical Innovation of China， 2021， 18（14）： -140

[Abstract] Objective： To investigate the effect of Sufentanil combined with Propofol in the large volume alveolar lavage in pneumoconiosis patients. Method： A total of 100 patients with pneumoconiosis admitted to Jiangxi Chest Hospital from January 2018 to June 2020 were selected， and all patients were treated with large volume alveolar lavage. According to random number table method， the patients were divided into observation group （n=50） and control group （n=50）. The control group was anesthetized by Remifentanil and Propofol， Sufentanil and Propofol were used in the observation group. Systolic blood pressure， heart rate， oxygen saturation， awakening time， recovery time of spontaneous respiration， extubation time， adverse reactions and degree of restlessness were compared between the two groups. Result： During the operation， the mean arterial pressure and heart rate of the observation group were higher than those of the control group， the differences were statistically significant （P<0.05）; there was no significant difference in blood oxygen saturation between the observation group and the control group （P>0.05）; the awakening time， recovery time of spontaneous respiration， and extubation time of the observation group were longer than those of the control group （P<0.05）; the incidence of ADR in the observation group was 4.0%， which was lower than 18.0% in the control group， the difference was statistically significant （P<0.05）; the SAS score of the observation group was lower than that of the control group （P<0.05）. Conclusion： Sufentanil combined with Propofol has obvious effect on the large volume alveolar lavage in pneumoconiosis patients， and has good sedative effect， promote recovery， reduce restlessness and high safety.

[Key words] Sufentanil Propofol Pneumoconiosis Large volume alveolar lavage

First-authors address： Jiangxi Chest Hospital， Nanchang 330006， China

doi：10.3969/j.issn.1674-4985.2021.14.033

大容量肺泡灌洗術在尘肺患者治疗中具有明显效果，可对肺泡腔、支气管树中炎性细胞、粉尘等予以清除，对患者呼吸功能具有明显改善作用，可促进临床症状改善，临床应用价值高[1]。但因采用大容量肺泡灌洗术治疗时，对患者实施麻醉时，容易有并发症发生，极有可能导致灌洗质量受到影响，还有可能使患者生命安全受到威胁，因此，选取适宜麻醉方法具有重要意义[2]。舒芬太尼是一种强效镇痛药物，复合丙泊酚在静脉麻醉中可充分发挥麻醉效果[3]。本研究选取50例尘肺患者，探讨舒芬太尼复合丙泊酚用于尘肺患者大容量肺泡灌洗术的效果，现将研究结果报道如下。……