基于络病理论探讨卵巢癌“抗血管生成”治疗机理

张玲 张梅

【摘 要】 肿瘤新生血管的形成是肿瘤生长和转移的重要原因之一。肿瘤血管除了为肿瘤本身提供充足的营养外，还能够使肿瘤向远处侵袭、播散，导致恶性肿瘤的生长、复发和转移。络病理论是中医基础理论的重要组成部分。临床实践中对许多疑难病的预防、诊断和治疗都是从络病的发病机理和临床表现入手的。基于此，文章尝试从中医“络病理论”的角度阐释卵巢肿瘤新生血管的理论基础，以期从“络病”的角度为卵巢恶性肿瘤的治疗探索新的理论思路。

【关键词】 络病理论;卵巢癌;抗血管生成;机理

【中图分类号】R737.31   【文献标志码】 A    【文章编号】1007-8517（2021）10-0001-04

Study on the Therapeutic Mechanism of “Anti-Angiogenesis” of Ovarian Cancer Based on Collateral Disease Theory

ZHANG Ling1 ZHANG Mei2*

1.Anhui University of traditional Chinese Medicine， Hefei 230000，China;

2.The first affiliated Hospital of Anhui Medical University， Hefei 230000，China

Abstract：One of the important factors of tumor growth and metastasis is the formation of tumor neovascularization， which can not only provide enough nutrition for the tumor itself， but also make the tumor invade and spread far away， leading to the growth， recurrence and metastasis of malignant tumor. Collateral disease theory is an important part of the basic theory of traditional Chinese medicine. The prevention and treatment of many difficult and complicated diseases in clinic are inspired by the pathogenesis characteristics and clinical manifestations of collateral disease theory. In view of this， from the point of view of TCM “collateral disease theory”， the author tries to make a preliminary explanation on the TCM theoretical basis of neovascularization of ovarian tumor， in order to explore a new theoretical groundwork for the treatment of ovarian malignant tumor from the point of view of “collateral disease”.

Keywords：Collateral Disease Theory; Ovarian Cancer; Anti-angiogenesis; Mechanism

卵巢惡性肿瘤（Ovarian cancer，OC）是目前生殖系统的三大恶性肿瘤之一，发病率居妇科恶性肿瘤第三位。由于其发病隐匿，早期症状不典型，诊断率低，预后差，其死亡率长期以来位居妇科恶性肿瘤的首位[1]。目前卵巢癌的治疗是以手术治疗为首选，辅以放疗、化疗、生物免疫治疗和中医中药等综合治疗。卵巢癌一旦确诊，应根据其临床分期和组织学类型制定合理、高效的治疗方案。对于初次手术之后的卵巢癌患者，如果联合化疗，大约75%的患者可以在2年内完全缓解[2]。但即便是初次治疗有效，最后仍然有60%～70%的患者复发。卵巢癌整体5年生存率只有大约20%～30%，复发性卵巢癌患者预后较差[3]。如何针对卵巢癌复发及转移进行治疗，是目前医学上的难点及焦点。“络病理论”是能有效指导疑难杂病诊治的一种理论，笔者以“络病理论”为切入点，综合卵巢癌的病因病机特点，为抗卵巢肿瘤新药尤其是中药肿瘤血管生成抑制剂的研制提供新的思路。……