小儿热速清颗粒治疗小儿肺炎支原体肺炎的临床效果

潘晓明 姚小飞 陈磊 龙章彪 黄俊

摘要 目的：探讨小儿热速清颗粒治疗小儿肺炎支原体肺炎的临床效果。方法：选取2018年1月至2019年12月马鞍山十七冶医院收治的肺炎支原体肺炎患儿81例作为研究对象。按照随机数字表法分为对照组（n=41）和观察组（n=40）。对照组采取阿奇霉素序贯治疗，观察组在对照组治疗方法基础上服用小儿热速清颗粒。比较2组的治疗效果、发热持续时间、咳嗽持续时间、肺部啰音持续时间、喘息消失时间、呼吸道炎症反应指标、肺功能指标、药物不良反应等。结果：观察组的治疗有效率高于对照组（P<0.05）。观察组的发热持续时间、咳嗽持续时间、肺部啰音持续时间、喘息消失时间短于对照组（P<0.05）。2组患儿在治疗后钙素原（Procalcitonin，PCT）、C反应蛋白（C-reactive Protein，CRP）、嗜酸性粒细胞计数（Eosinophil Count，EOS）均降低，第1秒钟用力呼气量（FEV1）、最大呼吸峰流速（PEF）、FEV1/用力肺活量（FVC）水平均增高。观察组的PCT、CRP、EOS低于对照组，FEV1、PEF、FEV1/FVC高于对照组（P<0.05）。2组的不良反应发生率差异无统计学意义（P>0.05）。结论：在肺炎支原体肺炎患儿的常規阿奇霉素序贯治疗过程中联合使用小儿热速清颗粒，有助于提升短期治疗效果，改善炎症反应指标以及肺功能指标，缩短病程，具有良好的安全性。

关键词 小儿热速清颗粒;肺炎支原体肺炎;急性炎性疾病;中成药;阿奇霉素;抗生素滥用;耐药性;肺功能

Effects of Xiaoer Resuqing Granules in the Treatment of Children with Mycoplasma Pneumoniae Pneumonia

PAN Xiaoming1，YAO Xiaofei1，CHEN Lei1，LONG Zhangbiao2，HUANG Jun3

（1 The 17th Metallurgical Hospital，Ma′anshan 243000，China; 2 The First Affiliated Hospital of Anhui Medical University，Hefei 230000，China; 3 The Second People′s Hospital of Ma′anshan 243000，China）

Abstract Objective：To explore the effects of Xiaoer Resuqing Granules on children′s mycoplasma pneumonia.Methods：From January 2018 to December 2019，a total of 81 child patients with mycoplasma pneumoniae pneumonia admitted to the Seventeenth Metallurgical Hospital were selected as the research objects.According to random number sampling method，they were divided into a control group（n=40）and an observation group（n=40）.The control group took azithromycin sequential treatment，and the observation group took Xiaoer Resuqing Granules on the basis of the control group.The curative effects，fever duration，cough duration，lung rales duration，wheezing disappearance time，respiratory tract inflammation indicators，lung function indicators，adverse drug reactions，etc.between the 2 groups were compared.Results：The curative effect the observation group was higher than that in the control group（P<0.05）.The duration of fever，the duration of cough，the duration of pulmonary rales，and the disappearance of wheezing in the observation group were shorter than those in the control group（P<0.05）.After treatment，PCT，CRP and EOS were all decreased in the 2 groups，and FEV1，PEF，FEV1/FVC levels increased.PCT，CRP，EOS of the observation group were lower than those of the control group，and FEV1，PEF，FEV1/FVC were higher than those of the control group（P<0.05）.The difference in the incidence of adverse reactions between the 2 groups was not statistically significant（P>0.05）.Conclusion：The combined use of Xiaoer Resuqing Granules in the routine azithromycin sequential treatment of child patients with pycoplasma pneumoniae pneumonia can help improve short-term treatment effects，improve inflammatory response indicators and lung function indicators，shorten the course of the disease，and have good safety.

Keywords Xiaoer Resuqing Granules; Mycoplasma Pneumoniae Pneumonia; Acute Inflammatory Diseases; Chinese Patent Medicine; Azithromycin; Antibiotic Abuse; Drug Resistance; Lung Function

中图分类号：R259;R563.1文献标识码：Adoi：10.3969/j.issn.1673-7202.2021.09.019

小儿支原体肺炎是儿童人群中十分常见的一类呼吸系统急症，目前已经证明肺炎支原体感染是导致小儿支原体肺炎的病因[1]。作为急性炎性疾病，患儿的呼吸道多发生病变，且临床表现较为类似，如咳嗽，发热，乏力，食欲减退，头痛等[2]。在肺炎支原体肺炎发病的过程中，儿童体内处于免疫紊乱状态，易诱发其他脏器的功能损伤，这对于儿童的生长发育以及健康影响较大。尤其在当今社会环境下，儿童的发病往往成为整个家庭的焦点，以此产生的人群健康损失以及经济损失等较为巨大[3]。……