《丹溪心法》治疗痰证的组方用药规律

于俏　吴焕林　孙海娇　林基伟

摘要 目的：剖析《丹溪心法》治疗痰证处方中各种药物的运用规律及其内在联系。方法：筛选《丹溪心法》中治疗痰证的方剂，构建其治疗痰证的方剂数据库。选用中医传承辅助平台（V2.5）软件作为分析软件，运用其关联规则算法及复杂系统熵聚法等方法进行数据挖掘研究，分析《丹溪心法》中治療痰证的方剂组方规律。结果：从《丹溪心法》中共筛选出161首治疗痰证方剂，对方剂组合进行分析，得出新处方7个，包括“青黛、海蛤、甘草、瓜蒌”“胆南星、半夏、桃仁、茯苓”等。结论：《丹溪心法》治疗痰证的药物中归于脾、胃经的占全部药物的76%，表明朱震亨治疗痰证重视脾胃，处方以益气化痰，兼以活血化瘀为主要原则。在此基础上形成治疗痰证的新处方，为痰证的新药研发提供了方向。

关键词 痰证;《丹溪心法》;诊断标准;组方用药规律;中医传承辅助平台;数据挖掘;配伍规律;中药有效成分

Analysis on the Prescribing Regularity for the Treatment of Phlegm Syndrome in Danxi′s Mastery of Medicine

YU Qiao1，WU Huanlin2，SUN Haijiao1，LIN Jiwei3

（1 Guangdong Provincial Hospital of Chinese Medicine，Guangzhou 510120，China; 2 Beijing University of Chinese Medicine，Beijing 100700，China; 3 Shenzhen Hospital of Chinese Traditional Medical， Shenzhen 518000，China）

Abstract Objective：To analyze regularity of compositions and medications for phlegm syndrome in Danxi′s Mastery of Medicine and their internal relations.Methods：The prescriptions and formula treating phlegm syndrome in Danxi′s Mastery of Medicine were collected，from which a database of formulas and medicines were established.The methods of data association rule algorithm and complex system entropy cluster were used to analyze the rules of prescription composition in Danxi′s Mastery of Medicine for the treatment of phlegm syndrome with the software of TCM Inheritance Support System（Version 2.5）.Results：Based on the analysis of totally 161 cases of prescriptions，the frequency of each herb included in the database was computed.The resulting new prescriptions contained “Indigo Naturalis，sea clam，Radix Glycyrrhizae，Fructus Trichosanthis” and “Rhizoma Arisaematis Cum Bile，Rhizoma Pinelliae，Semen Persicae，Poria”，etc.Conclusion：76% of the drugs for phlegm syndrome in Danxi′s Mastery of Medicine belong to meridians of spleen and stomach.It prompts that in ZHU Danxi′s academic thoughts of phlegm syndrome，regulating spleen and stomach is emphasized.The prescription is based on the principle of benefiting qi and reducing phlegm，and promoting blood circulation and removing blood stasis.On this basis，a new prescription for the treatment of phlegm syndrome is formed，which provides direction for the research and development of new drugs for phlegm syndrome.

Keywords Phlegm syndrome; Danxi Xinfa; Diagnostic criteria;Laws of compositions and medications; TCM Inheritance Support System; Data mining; Formulating rules; Effective components of Traditional Chinese Medicine

中图分类号：R256;R289文献标识码：Adoi：10.3969/j.issn.1673-7202.2021.12.024

朱震亨是中国金元时期著名四大医家之一。其对杂病的治疗颇有心得，故后世亦有“杂病宗丹溪”之说。丹溪论治杂病，多将其病因归结于“痰”，提倡“百病兼痰”，其观点为后世痰证学的发展奠定了基础。目前临床上一些常见慢性病，如冠心病、高脂血症、高血压等常迁延难愈，而选择从“痰”论治作为治疗的突破点[1-7]，却能收到满意疗效。2016年由广东省中医院国医大师邓铁涛教授学术继承人吴焕林教授牵头制定的《中医痰证诊断标准》，丰富及明确了“痰”的内涵，并制定出痰证统一化诊断标准[8]。……