循环纤维细胞与心肌梗死后心室重塑相关研究进展

罗彦梦 陶四明

[摘要]心肌梗死后心室重塑严重危害患者的长期健康。来源于骨髓的循环纤维细胞在心肌纤维化的发生和发展过程起重要作用，其能够分泌细胞外基质参与纤维化，并对损伤组织进行修复。然而，过度的纤维化又将导致心肌梗死后心力衰竭或心律失常，严重损害患者的预后。因此，心肌梗死后如何抑制或改善患者心室重构的严重程度及改善患者长期预后成为冠心病目前临床研究的热点。同时，如何调节循环纤维细胞在心肌梗死后心室重塑的促进作用，成为延缓心肌梗死后心室重塑研究重点。在本文中对近年来循环纤维细胞与心室重塑相关性的研究进展进行综述。

[关键词]循环纤维细胞;成纤维细胞;肌成纤维细胞;冠心病;心室重塑

[中图分类号] R542.22 [文献标识码] A  [文章编号]2095-0616（2021）22-0027-04

Research progress on correlation between circulating fibroblasts and ventricular remodeling after myocardial infarction

LUOYanmeng1 TAOSiming

1. Clinical Medical College， Dali University， Yunnan， Dali 617000， China;2. Department of Cardiology， Affiliated Hospital of Yunnan University， Yunnan， Kunming 650000， China

[Abstract] Ventricular remodeling after myocardial infarction seriously endangers the long-term health of patients. Circulating fibroblasts derived from bone marrow play an important role in the occurrence and development of myocardial fibrosis， which can secrete extracellular matrix to participate in fibrosis and repair damaged tissues. However， excessive fibrosis will lead to heart failure or arrhythmia after myocardial infarction， which will seriously affect the prognosis of patients. Therefore， how to inhibit or improve the severity of ventricular remodeling and improve the long-term prognosis of patients after myocardial infarction has become a hot spot in clinical research of coronary heart disease. At the same time， how to regulate the role of circulating fibroblasts in promoting ventricular remodeling after myocardial infarction has become the research focus of delaying ventricular remodeling after myocardial infarction. In this paper， the research progress of the correlation between circulating fibroblasts and ventricular remodeling in recent years is reviewed.

[Key words] Circulating fibroblasts; Fibroblast; Myofibroblast; Coronary heart disease; Ventricular remodeling

隨着我国人口老龄化和社会经济的发展，心血管病的发病率和患病率明显升高。目前我国心血管病患病人数为2.9亿，而冠心病患者已达到了1100万[1]。随着医疗水平的提高和冠脉介入手术的普及，冠心病心肌梗死急性期死亡率逐渐降低，但心肌梗死后心室重塑造成的慢性心力衰竭及心律失常却在逐年增加，严重影响冠心病患者的生存及预后。因此，如何通过有效方法来抑制循环纤维细胞向成纤维细胞过度转化和增殖，来改善冠心病心肌梗死后患者的远期预后成为目前临床治疗的重要方式。本文从循环纤维细胞对心室重塑的研究现状和治疗进展进行综述，来进一步阐述两者之间相关性并探讨通过循环纤维细胞靶点干预心脏重塑的理论依据。……