四联疗法治疗幽门螺杆菌阳性的慢性荨麻疹临床观察

【摘要】目的：观察四联疗法治疗幽门螺杆菌阳性的慢性荨麻疹临床效果。方法：在我院2018年9月至2019年9月期间收治的所有慢性荨麻疹合并幽门螺杆菌感染患者中随机抽取126例，采用不同的治疗方式进行治疗，并将此作为依据平均分成两组，保证每组各有患者63例。对照组患者采用常规抗组胺疗法进行治疗，而实验组则在此基础上加用四联疗法进行治疗，比较两组患者经过治疗之后所产生的临床效果以及不良反应发生率。结果：实验组患者的不良反应发生率显著低于对照组，而治疗有效率相反高于对照组，差异表示统计学意义显著（P<0.05）。结论：采用四联疗法治疗慢性荨麻疹合并幽门螺杆菌感染者可取得显著的临床治疗效果，不仅如此还能够有效降低患者的不良反应发生率，具有极高的临床应用价值。

【关键词】幽门螺杆菌阳性；慢性荨麻疹；四联疗法；临床效果

[中图分类号]R758.24 [文献标识码]A [文章编号]2096-5249（2021）09-0061-02

Clinical observation of quadruple therapy in the treatment of chronic urticaria with Helicobacter pylori positive

ZHOU Wei （General Hospital of Guizhou Panjiang investment holding （Group） Co.， Ltd./Gangouqiao General Hospital of panzhou， Liupanshui Guizhou 553536， China）

[Abstract] Objective： To observe the clinical effect of quadruple therapy in the treatment of chronic urticaria with Helicobacter pylori positive. Methods： 126 patients with chronic urticaria complicated with Helicobacter pylori infection in our hospital from September 2018 to September 2019 were randomly selected and treated with different treatment methods. They were equally divided into two groups according to this， with 63 patients in each group. The control group was treated with conventional antihistamine therapy， while the experimental group was treated with quadruple therapy on the basis of conventional antihistamine therapy. Results： the incidence of adverse reactions in the experimental group was significantly lower than that in the control group， while the effective rate was higher than that in the control group， the difference was statistically significant （P<0.05）. Conclusion： quadruple therapy in the treatment of chronic urticaria with Helicobacter pylori infection can achieve significant clinical effect， not only that， but also can effectively reduce the incidence of adverse reactions in patients with high clinical application value.

[Key words] Helicobacter pylori positive； Chronic urticaria； Quadruple therapy； Clinical effect

慢性蕁麻疹是一种严重影响患者生活质量的皮肤病，属于变态反应性疾病之一，患者在患病后可表现为风团反复性发作，且伴有剧烈的瘙痒症状，一般情况下症状可持续六周以上的时间。慢性荨麻疹病程较长、致病因素多样且复杂、治疗效果欠佳， 对患者身体健康水平与生活质量均构成不同程度的影响。最近几年中， 国内外临床上针对慢性荨麻疹与幽门螺杆菌两者关系的研究不断深入化， 有学者认为， 幽门螺杆菌感染不能完全解除是导致慢性荨麻疹患者疗效欠佳的主要原因。既往也有研究指出， 幽门螺杆菌可能参与慢性荨麻疹的发病机制， 其通过增加胃黏膜血管的通透性， 诱发机体和食物变应原相接触的概率增加；……