刘念

【摘要】目的:在ABO新生儿溶血病患儿输血前分别应用两种检测技术,并分析其应用价值。方法:选取68例ABO新生儿溶血病患儿,均进行MGT、MPT检测,分析配血结果。结果:68例患者,交叉配血386次,直接抗人球蛋白阳性、阴性患者的血清、放散液MPT、MGT检测不合格率均有明显差异(P<0.05)。结论:在ABO新生儿溶血病患儿输血前进行MGT检验不合格率更低,有利于保障输血安全。
【关键词】ABO新生儿;溶血病;配血
[中图分类号]R722.18;R446 [文献标识码]A [文章编号]2096-5249(2021)09-0156-02
Application of microcolumn gel technology in blood transfusion test for children with ABO hemolytic disease of newborn
LIU Nian(Department of blood transfusion, peoples Hospital of Rongxian County, ZigongSichuan 6431000, China)
[Abstract] Objective: To apply two detection techniques before blood transfusion in ABO children with hemolytic disease of newborn and analyze their application value. Methods: 68 cases of ABO neonatal hemolytic disease were selected, Mgt, MPT detection, blood matching results were analyzed. Results: Among 68 patients, 386 times of cross matching, the unqualified rates of MPT and Mgt in serum and effusion of patients with direct anti human globulin positive and negative patients were significantly different(P<0.05). Conclusion: The unqualified rate of Mgt test before blood transfusion in ABO children with hemolytic disease of newborn is lower, which is conducive to ensure the safety of blood transfusion.
[Key words] ABO neonate; Hemolytic disease; Blood matching
ABO新生兒溶血是一种常见的新生儿溶血病,患儿血型一般为A型、B型,母体血型为O型,从其发生原因上看,主要为母体与婴儿血型无法吻合导致新生儿、胎儿出现免疫性溶血[1]。对于该类新生儿,在输血治疗时若按常规方法同型输血则可能导致溶血反应加重,因此,为确保输血安全,应采取可靠的检验方法。微柱凝胶技术(Microbubes gel technology, MGT)、微孔板凝聚胺技术(Maintenance panel trainer, MPT)均是目前临床上常用的检测技术[2],为对比两者的敏感度及准确度,本文将在ABO新生儿溶血病患儿输血前分别应用两种检测技术,并分析其应用价值,现将详细结果报道如下。
1 资料与方法
1.1一般资料 选取在我院治疗的68例ABO新生儿溶血病患儿,病例纳入时间为2018年8月至2020年7月。纳入标准:①符合ABO新生儿溶血病诊断标准,血清胆红素水平升高,黄疸改善后出现严重贫血,母体血型为O型,患儿RHD血型检测阳性;②临床资料完整;③监护人对本次研究知情同意。排除标准:①有心脏病家族史患儿;②有精神疾病家族史患儿;③有药物过敏史患儿等。随机分为两组。其中男性患儿37例、女性患儿31例,年龄在1~5 d,平均年龄(2.78±0.67)d,体质量2.41~3.30 kg,平均体质量(2.98±0.13)kg。……