胰岛素强化治疗对初诊2型糖尿病患者疗效及胰岛功能的影响研究

王伟

【摘要】目的：觀察胰岛素强化治疗初诊2型糖尿病并分析对胰岛功能的影响。方法：选取2015年10月至2018年10月期间我院收治的2型糖尿病患者80例作为研究对象，随机分为实验组和对照组，对照组患者给予常规胰岛素治疗，实验组患者给予胰岛素强化治疗，观察并对比两组患者治疗前后的空腹血糖、餐后2 h血糖、糖化血红蛋白、胰岛素分泌指数、胰岛素抵抗指数以及胰岛素敏感指数等指标，分析胰岛素强化治疗对2型糖尿病患者的疗效及胰岛功能的影响。结果：两组患者治疗前的空腹血糖、餐后2 h血糖以及糖化血红蛋白等指标比较差异没有统计学意义（P>0.05）；实验组患者治疗后的空腹血糖明显低于对照组患者治疗后，两组患者治疗后的空腹血糖、餐后2 h血糖以及糖化血红蛋白比较差异具有统计学意义（P<0.05）。两组患者治疗前的胰岛素分泌指数、胰岛素抵抗指数以及胰岛素敏感指数比较没有明显差异（P>0.05）；治疗前后两组患者胰岛素分泌指数、胰岛素抵抗指数以及胰岛素敏感指数组内比较差异均具有统计学意义（P<0.05）。结论：胰岛素强化治疗2型糖尿病疗效显著，可有效控制患者的血糖，利于胰岛功能的恢复，具有临床应用价值。

【关键词】胰岛素强化治疗；2型糖尿病；临床疗效；胰岛功能

[中图分类号]R587.1 [文献标识码]A [文章编号]2096-5249（2021）11-0053-02

Effects of intensive insulin therapy on the efficacy and islet function in newly diagnosed type 2 diabetic patients

WANG Wei （Community health service center， Xicheng District， Beijing 100031， China）

[Abstract] Objective： To observe the effect of intensive insulin therapy on newly diagnosed type 2 diabetes Mellitus （T2 dM）. Methods： 80 patients with type 2 diabetes from October 2015 to October 2018 were randomly divided into experimental group and Control Group. The patients in the Control Group were given conventional insulin therapy， patients in the experimental group were given intensive insulin therapy， the Fasting Blood Glucose， 2h Postprandial Blood Glucose， Glycated hemoglobin， Insulin Secretion Index， Insulin Resistance Index and insulin sensitivity index were observed and compared between the two groups， objective： to analyze the effect of intensive insulin therapy on type 2 diabetic patients and the function of pancreatic islets. Results： There was no significant difference between the two groups in fasting blood glucose before treatment， 2h Postprandial Blood Glucose and Glycated Hemoglobin（P>0.05）The Fasting Blood Glucose after treatment in the experimental group was significantly lower than that in the control group， and there were significant differences in fasting blood glucose， 2 hours Postprandial Blood Glucose and Glycated hemoglobin between the two groups（P<0.05）. There was no significant difference in Insulin Secretion Index， Insulin Resistance Index and insulin sensitivity index between the two groups before Treatment（P>0.05）There were significant differences in insulin secretion index， Insulin Resistance Index and insulin sensitivity index between the two groups before and after Treatment（P<0.05）. Conclusion： Intensive Insulin Treatment of Type 2 diabetes Mellitus is effective， can effectively control the blood sugar， is conducive to the recovery of islet function， has clinical application value.

[Key words] Intensive insulin therapy； Type 2 diabetes mellitus； Clinical efficacy； Islet function

糖尿病是临床上的常见病和多发病，且随着病程的延长，糖尿病会出现糖尿病肾病、眼病以及糖尿病血管性病变，严重损害患者的心身健康，甚至威胁患者的生命[1-3]。……