妊娠高血压危象治疗中硝酸甘油+硫酸镁及酚妥拉明+硫酸镁的应用效果

朱孝梅

摘要：目的 妊娠高血压危象治疗中硝酸甘油+硫酸镁及酚妥拉明+硫酸镁的应用效果。方法 选取2019年8月-2020年8月我院收治的妊娠高血压危象患者共80例，随机分为观察组和参照组，各40例。两组均应用硫酸镁治疗，参照组在硫酸镁基础上应用酚妥拉明，观察组在硫酸镁基础上应用硝酸甘油。比较两组患者的临床效果、不良反应发生率。结果 两组临床有效率比较存在差异，观察组有效率高于参照组，差异明显（P<0.05）。两组不良反应发生率比较无明显差异（P>0.05）。结论 硝酸甘油联合硫酸镁治疗妊娠高血压危象效果理想，且不会增加不良反应发生率，具有推广的价值。

关键词：妊娠高血压危象;硝酸甘油;硫酸镁;酚妥拉明

[Abstract] Objective To evaluate the effect of nitroglycerin + magnesium sulfate and phentolamine + magnesium sulfate in the treatment of pregnancy induced hypertension crisis. Methods a total of 80 patients with pregnancy induced hypertension crisis treated in our hospital from August 2019 to August 2020 were randomly divided into observation group and reference group，with 40 cases in each group. Both groups were treated with magnesium sulfate，the reference group was treated with phentolamine on the basis of magnesium sulfate，and the observation group was treated with nitroglycerin on the basis of magnesium sulfate. The clinical effect and incidence of adverse reactions were compared between the two groups. Results there were significant differences in the clinical effective rate between the two groups. The effective rate of the observation group was higher than that of the reference group（P < 0.05）. There was no significant difference in the incidence of adverse reactions between the two groups（P > 0.05）. Conclusion nitroglycerin combined with magnesium sulfate is effective in the treatment of pregnancy induced hypertension crisis，and will not increase the incidence of adverse reactions.

【 key words 】 pregnancy induced hypertension crisis;glyceryl trinitrate;magnesium sulphate;Phentolamine

妊娠高血壓危象是一种常见的妊娠期疾病，此病的病情较为凶险，且进展迅速，其发展严重时会严重损害患者的心、脑、肾等器官，继而威胁到母婴安全【1】。目前的研究指出【2】，此病的发生同原发性高血压、糖尿病等有关。而在此病发生后，临床要及时对患者进行干预治疗，以保证母婴安全。鉴于此，此次研究将围绕着妊娠高血压危象治疗中硝酸甘油+硫酸镁及酚妥拉明+硫酸镁的应用效果进行分析论述，具体如下：

1资料方法

1.1研究资料

选取2019年8月-2020年8月我院收治的妊娠高血压危象患者共80例，随机分为观察组和参照组，各40例。参照组年龄24-34岁，平均年龄（30.17±1.11）岁;观察组年龄24-35岁，平均年龄（30.69±1.35）岁;初产妇44例，经产妇36例。以上基本资料无显著差异（P>0.05）。纳入标准：纳入研究的患者均符合妊娠高血压危象的诊断标准;对此次研究知情且同意加入;排除标准：合并其他严重妊娠并发症者;存在精神病史者;药物禁忌者;诊治资料不完整者。