邹丽敏


【摘要】目的:分析血清免疫球蛋白检验在慢性乙型肝炎检验内的应用价值。方法:选择研究对象总计40例,均为我院慢性乙型肝炎患者,实验时间段为2021年2月—2023年2月,名为观察组;同期40例健康体检人员为对照组,两组均实施血清免疫球蛋白检验,对比两组相关指标。结果:血清免疫球蛋白数值对比,观察组更高(P<0.05);总胆红素对比,观察组更低(P<0.05);观察组白蛋白以及凝血酶原活动度显著低于对照组(P<0.05)。结论:血清免疫球蛋白检验可精准诊断慢性乙型肝炎,可推广使用。
【关键词】血清免疫球蛋白检验;慢性乙型肝炎;疗效
Hepatitis b patients serum immunoglobulin clinical inspection value analysis
ZOU Limin
Danyang Peoples Hospital, Danyang, Jiangsu 212300, China
【Abstract】Objective: To analyze the application value of serum immunoglobulin test in the detection of chronic hepatitis B.Methods: A total of 40 patients with chronic hepatitis B in our hospital were selected as the observation group, and the experimental period was from February 2021 to February 2023. During the same period, 40 healthy persons were selected as the control group. Serum immunoglobulin test was performed in both groups, and the related indicators of the two groups were compared. Results: The serum immunoglobulin values in the observation group were higher than those in the control group (P<0.05); The total bilirubin in the observation group was lower than that in the control group(P<0.05); The albumin and prothrombin activity in the observation group were significantly lower than those in the control group(P<0.05). Conclusion: Serum immunoglobulin test can accurately diagnose chronic hepatitis B and can be widely used.
【Key Words】Serum immunoglobulin test; Chronic hepatitis B; Efficacy
我国大约有1.2千万乙肝病毒携带者,3千万是慢乙肝病人[1]。其中10%~20%的病人会发展为肝硬化,1%~5%的病人会发展为肝癌。乙肝病毒严重威胁着人们生命健康的一种病毒。其作用机制是诱导机体产生的免疫应答,从而造成肝脏疾病。研究表明,在乙型肝炎病毒(hepatitis B virus, HBV)感染的慢性乙型肝炎病人中,由于血清免疫球蛋白升高及补体水平降低,使其对HBV感染的清除及对HBV感染的清除能力降低,进一步加重了病人肝脏的免疫损伤[2]。IgG,IgA,IgM是人体的三种主要的免疫球蛋白。三个单克隆抗体在结构与功能上均有差异。二次免疫反应的抗体以IgG为主,一次免疫反应的抗体以IgM為主,而一次免疫反应的抗体以IgA为主[3]。本文选择了慢性乙肝患者和健康体检人员作为研究对象,对其进行了血清免疫球蛋白检测,并将其与有关指标进行了比较,以分析其在慢性乙肝患者中的应用价值,现报告如下。
1.1 一般资料
观察组研究对象为慢性乙型肝炎,研究数量为40例,研究时间段为2021年2月—2023年2月,男27例,女13例,年龄32~72岁,平均年龄(54.58±9.12)岁;……