多囊卵巢综合征患者抗氧化及蛋白代谢的变化研究

袁迎九　后建丽　丁文清

[摘要]目的 研究与观察多囊卵巢综合征（PCOS）患者抗氧化及蛋白代谢的变化情况。方法 选取2016年10月～2017年6月在我院就诊的70例PCOS患者为观察组，选择同期70名健康同龄妇女为对照组。检测两组研究对象的抗氧化及代谢指标，并比较两组的检测结果，同时比较观察组不同严重程度PCOS患者的检测结果，以Logistic回归分析处理上述检测指标与PCOS的关系。结果 观察组的清蛋白代谢指标及MDA高于对照组，差异有统计学意义（P<0.05），其他血清抗氧化指标低于对照组（P<0.05），不同严重程度PCOS患者的检测结果比较，差异有统计学意义（P<0.05），且Logistic回归分析处理结果显示，上述检测指标与PCOS有密切的关系（P<0.05）。结论 PCOS患者抗氧化及蛋白代谢指标明显不同健康同龄妇女，上述指标与PCOS有密切的关系，可作为疾病诊断与治疗的指导性指标。

[关键词]多囊卵巢综合征；抗氧化指标；蛋白代谢指标

[中图分类号] R711.6 [文献标识码] A [文章编号] 1674-4721（2017）12（b）-0162-03

[Abstract]Objective To study and observe the change status of antioxidation and protein metabolism of patients with polycystic ovary syndrome （PCOS）.Methods 70 patients with PCOS in our hospital from October 2016 to June 2017 were selected as the observation group，70 healthy women with the same age at the same time were selected as the control group.Then the antioxidation and protein metabolism indexes of two groups were detected，and the detection results of two groups were compared，the detection results of observation group with different severity degree of PCOS were compared too，and the relationship between those detection indexes and PCOS were analyzed by the Logistic regression analysis.Results The serum protein metabolism indexes and MDA of observation group were all higher than those of control group（P<0.05），other serum antioxidation indexes were lower than those of control group（P<0.05），the detection results of observation group with different severity degree of PCOS were compared，there were significant differences （P<0.05），and the results of Logistic regression analysis showed，those detection indexes all had close relationship to PCOS，the difference was statistically significant（P<0.05）.Conclusion The antioxidation and protein metabolism of patients with PCOS are obviously different to the results of healthy women with the same age，and those indexes all have close relationship to PCOS，and they can be as the guidance indexes of the disease.

[Key words]Polycystic ovary syndrome；Antioxidation indexes；Protein metabolism indexes

多囊卵巢综合征（PCOS）是育龄妇女的常见病，患者可表现出多毛、月经异常甚至不孕，而上述表现也是患者就诊的主要原因。临床关于PCOS的研究多见[1-2]，而本病作为内分泌与代谢异常所致疾病，对于患者机体代谢方面的研究则相对多见，而蛋白代谢方面的研究虽可见，但研究结果的差异较大。另外，抗氧化能力作为反应机体代谢的重要方面[3]，其在PCOS发生发展中的作用研究也可见，但也存在研究差异明显的情况。因此，本文对PCOS患者抗氧化及蛋白代谢的变化情况进行探究，现报道如下。

1资料与方法

1.1一般资料

选取2016年10月～2017年6月在我院就诊的70例PCOS患者为观察组，选取同期70例健康同龄妇女为对照组。对照组年龄21～38岁，平均（29.9±6.7）岁；有生育史40例，无生育史30例。观察组年龄22～38岁，平均（29.6±7.1）歲；有生育史38例，无生育史32例；病程7～50.5个月，平均（26.3±5.7）个月；严重程度：轻度20例，中度32例，重度18例。两组妇女的年龄与生育史等情况比较，差异无统计学意义（P>0.05），具有可比性。本研究经我院医学伦理学委员会批准。endprint