晚期胃癌组织中STMN1 mRNA的表达水平与预后及紫杉醇化疗疗效的关系

胡俊 陈武 陈军

[摘要] 目的 研究晚期胃癌肿瘤组织中STMN1的表达水平，分析其生存时间、转移及紫杉醇联合化疗疗效之间的关系。方法 通过分析39例晚期胃癌患者组织中STMN1 mRNA的表达水平，并与患者的发生部位、分化程度、病理学类型、生存时间、远处转移及紫杉醇联合化疗疗效之间的关系进行分析。 结果 在不同发生部位、病理学类型中STMN1的表达无差异，低分化组织中STMN1表达高，阴性表达患者的中位生存时间长且远处转移机会少，STMN1表达水平与紫杉醇化疗疗效呈负相关。 结论 STMN1 mRNA的表达水平可以作为评介胃癌预后的独立因素，并可作为遴选化疗药物，进行个体化治疗的指标。

[关键词] 人微管去稳蛋白；预后；紫杉醇

[中图分类号] R735.2[文献标识码] B[文章编号] 1673—9701（2012）25—0038—02

Advanced gastric carcinoma STMN1 mRNA expression levels and the prognosis andpaclitaxelchemotherapycurative effect

HUJun CHENWu CHEN Jun

Department of Oncology，Xingan County People's Hospital，Xingan 331300，China

[Abstract] Objective This paper studied the expression level of STMN1 in advanced gastric tumor tissue，analyzing the relationship between the survival time，transfer and paclitaxel combination chemotherapy effect. Methods The authors detected 39 cases of advanced gastric cancer tissue of patients with STMN1 mRNA expression levels，and analysis of the relationship between patients with the different sick locations，degree of differentiation，pathological type，survival time，distant metastasis and paclitael combination chemotherapy curative effect. Results Whether in different sick locations or in different pathological types. The STMN1 of differentiation expressed high，negative expression in patients with median survival time was long and distant metastases with fewer opportunities，the expression level of STMN1 and paclitaxel chemotherapy efficacy was negatively related. Conclusion The STMN1 mRNA expression levels can be used as independent prognostic factors in gastric cancer， and also can serve as the selection of chemotherapeutic drugs and individual treatment indicators.

[Key words] STMN1；Prognosis；Paclitaxel

晚期胃癌的主要治疗手段是化疗，传统方案以氟尿嘧啶、顺铂或阿霉素为主，但有效率低，仅为20%～30%，中位生存时间短，为5～6个月[1]。紫杉醇是一种新型抗微管药，通过促进微管蛋白装配成微管，并抑制其解聚，影响细胞的有丝分裂和增殖。紫杉类药物联合方案化疗增加了疗效，但在不同敏感个体间疗效差异较大，探讨个体化治疗成为当前趋势。STMN1（Stathmin，又称oncoprotein18）基因编码的STMN1蛋白通过促进微管的解聚或阻止微管的聚合从而影响有丝分裂纺锤体的形成，通过抑制其表达，可以干扰恶性肿瘤细胞的有丝分裂，研究其表达与紫杉醇联合化疗远期疗效及预后的影响，以期为晚期胃癌的综合治疗及预后判断提供有价值的指标。……