成智 曹静华 贺丰
[摘要] 目的 了解单纯及混合其他细菌感染的肺炎支原体肺炎患儿临床表现差异。 方法 选择52例单纯肺炎支原体肺炎及31例混合细菌感染的肺炎支原体肺炎患儿临床资料,对其临床表现进行对比分析。 结果 混合感染组平均热程、住院天数长于单纯感染组(均P < 0.05);两组患儿白细胞计数及中性粒细胞计数值差异有统计学意义(均P < 0.05),CRP值差异无统计学意义(P > 0.05);混合感染组患儿肺不张发生率增高(P < 0.05),胸膜炎发生率差异无统计学意义(P > 0.05)。 结论 两组患儿临床表现存在一定差异,混合细菌感染是肺炎支原体肺炎病情迁延、难愈的因素之一。
[关键词] 肺炎支原体;细菌感染;临床特点;儿童
[中图分类号] R725.6[文献标识码] B[文章编号] 1673—9701(2012)24—0033—02
Clinical contrast analysis of simple mycoplasma pneumoniae pneumonia or concurrent bacterial infection
CHENG Zhi CAO Jinghua HE Feng
Department of Pediatrics, Xiangtan Central Hospital in Hunan Province, Xiangtan 411100, China
[Abstract] Objective To investigate the difference of clinical manifestation of simple mycoplasma pneumoniae pneumonia or concurrent bacterial infection in children. Methods The clinical manifestation was contrast analyzed between simple mycoplasma pneumoniae pneumonia group (52 cases) and concurrent bacterial infection group (52 cases). Results The average heating times and inpatient days of concurrent bacterial infection group were significantlylonger than simple mycoplasma pneumoniae pneumonia group (all P < 0.05). There were statistical differences of WBC and neutrophil between two groups (P = 0.03,P = 0.03) and CRP had no statistical difference (P > 0.05). The incidence rates of atelectasis of concurrent bacterial infection group were significantly higher than simple mycoplasma pneumoniae pneumonia group (P < 0.05). The incidence rates of pleuritis had no statistical difference (P > 0.05). Conclusion There are some difference of clinical manifestation between two groups and concurrent bacterial infection is the factor to affect the patient''s condition and healing of mycoplasma pneumoniae pneumonia.
[Key words] Mycoplasma pneumoniae; Bacterial infection; Clinical characteristics; Children
肺炎支原体肺炎(mycoplasma pneumoniae pneumonia,MPP)是一种儿童常见的社区获得性肺炎。近年来难治性及重症MPP逐年增多,其中肺炎支原体混合其他病原感染是导致其病情复杂、迁延不愈的重要因素之一。本研究通过对比MPP及混合细菌感染的MPP临床表现、实验室检查及胸部影像表现,就其差异加以探讨,现报道如下。
1 资料与方法
1.1 一般资料
连续选择2010年5月~2011年11月于我院儿科住院的患者102例,参照2006年《儿童社区获得性肺炎管理指南(试行)》[3]:单份MP—IgM抗体滴度≥1∶160,双份血清抗体滴度≥4倍升高,或MP—IgM抗体阴转阳改变;肺部影像证实肺炎改变。排除标准:同时合并病毒感染者19例。本研究病例共83例,其中男27例,女56例,年龄2~14岁,中位年龄6.59岁。根据是否混合细菌感染分为单纯肺炎支原体肺炎组52例和混合细菌感染肺炎支原体肺炎组31例,两组患者的性别(P = 0.60 > 0.05)、平均年龄(P = 0.28 > 0.05)差异无统计学意义,具有可比性。
1.2 检查方法
患儿入院后抽取静脉血,采用被动免疫凝集法检测血清MP—IgM(日本瑞必欧株式会社试剂),并于入院次日清晨由护士采用一次性负压抽吸深部痰送检,送检标本分别接种于MH琼脂及哥伦比亚血琼脂平板。分纯……