引入地西泮对速眠新复合氯胺酮麻醉效果的改进观察

技术方法

引入地西泮对速眠新复合氯胺酮麻醉效果的改进观察

曹春艳，康宁，严笠，胡正云，申志惠，肖苒

(中国医学科学院北京协和医学院整形外科医院，北京100144)

【摘要】目的改进速眠新单纯与复合麻醉方法的不足，观察引入地西泮对速眠新复合盐酸氯胺酮麻醉效果的影响。方法成年实验家兔80只，雌雄各半，随机分为A、B、C三组，A组肌肉注射速眠新(0.3 mL/kg),B组肌肉注射速眠新复合盐酸氯胺酮混合液(0.3 mL/kg)，C组肌肉注射速眠新复合盐酸氯胺酮混合液(0.3 mL/kg)，并静注地西泮注射液(1.5 mL/kg)，对比三组的麻醉效果、麻醉显效时间、初次麻醉维持时间、总麻醉药用量及总手术时间。结果C组麻醉显效时间明显短于A、B组(P<0.01)；初次麻醉维持时间C组长于A、B组(P<0.01)；总麻醉药用量C组明显少于A、B组(P<0.01)；C组总的手术时间少于A、B两组(P<0.01)；C组的麻醉效果优于A、B组(P<0.01)。结论采用速眠新、盐酸氯胺酮联合地西泮复合麻醉明显提高了麻醉效果，是适于家兔敏感手术部位及手术时间较长的动物实验的理想麻醉方法。

【关键词】麻醉；速眠新；氯胺酮；地西泮；兔

[作者简介]曹春艳(1965-)，女，主管技师，研究方向：医学动物实验教学与实验动物麻醉。

[通讯作者]肖苒(1970-)，女，研究员，研究方向：基础医学研究。Email: rxiao163@163.com。

【中图分类号】R332【文献标识码】 A

doi:10.3969.j.issn.1671.7856. 2015.001.013

Experimental observation of aesthetic effects of introducing diazepam

into combined aesthesia of Sumianxin and Ketamine hydrochloride

CAO Chun-yan，KANG Ning，YAN Li，HU Zheng-yun，SHEN Zhi-hui，XIAO Ran

(Research Center of Plastic Surgery Hospital, Chinese Academy of Medical Sciences &

Peking Union Medical College, Beijing 100144, PR China)

Abstract【】Objective To observe the effectiveness of introducing Diazepam into combined aesthesia of Sumianxin and ketamine hydrochloride. MethodA total of 80 rabbits of both genders for operation were randomly divided into A, B and C groups. The A group was injected with Sumianxin intramuscularly (0.3 mL/kg by weight). The B group was injected with Sumianxin and ketamine hydrochloride intramuscularly (0.3 mL/kg by weight). The C group was injected with Diazepam intravenously (1.5 mL/kg by weight) combined with Sumianxin and ketamine hydrochloride injected intramuscularly (0.3 mL/kg by weight). The aesthetic effects, induction time, anesthesia maintaining time, total anaesthetic dose and operation time were observed, recorded and compared. ResultThe induction time of the C group was significantly shorter than A and B groups (P<0.01). The initial anesthesia maintaining time of the C group was the longest among the three (P<0.01) with least total anaesthetic dose (P<0.01). The operation time of the C group was the least with best aesthetic effects (P<0.01). ConclusionIntroducing Diazepam into combined aesthesia of Sumianxin and ketamine hydrochloride can improve the aesthetic effects. Therefore, this is an optional aesthetic method for time-consuming animal operation or sensitive surgical sites of rabbits.

【Key words】Anesthesia；Sumianxin；Ketamine hydrochloride；Diazepam；Rabbit

复合麻醉是由两种或两种以上的麻醉药物或麻醉方法同时或先后应用，以达到完善的术中及术后镇痛效果。因为它的全麻药用量少及副作用小等特点，已逐渐成为动物医学领域的主要流行趋势[1]。麻醉药及麻醉方法的选择，不仅考虑手术部位，还应考虑手术时间长短[2]。过去所采用的速眠新以及目前最常用的速眠新复合氯胺酮的麻醉方法，存在麻醉不全、麻醉维持时间短及麻醉深度不够等缺点，不能满足一些敏感部位和对镇痛要求比较高的手术时间长的动物外科手术。……