复合磷酸酯酶肠溶片治疗肝病患者腹胀的疗效分析

·临床药学·

复合磷酸酯酶肠溶片治疗肝病患者腹胀的疗效分析

牛庆慧1，边城1，江月萍2，杨玉玲1，刘培1，张凤娟1，张晗1

(1.青岛大学附属医院感染科，山东 青岛 266555；2.青岛大学附属医院消化科,山东 青岛 266003)

摘要：目的评价复合磷酸酯酶肠溶片对乙型病毒性肝炎腹胀患者的疗效，并与复方消化酶进行比较。方法107例慢性乙型病毒性肝炎以腹胀为主要症状的患者，分为复合磷酸酯酶肠溶片14 d组(1组)25例，复合磷酸酯酶肠溶片28 d组(2组)27例；复方消化酶14 d组(3组)28例，复方消化酶28 d组(4组)27例。治疗结束后观察患者腹胀的缓解率和不良反应。采用意向性分析和符合方案分析，进行卡方检验。结果复合磷酸酯酶肠溶片14 d组、复合磷酸酯酶肠溶片28 d组、复方消化酶14 d组、复方消化酶28 d组治疗后腹胀均有所缓解，行意向性分析分别为88.0%、92.6%、89.3%、96.3%，各组比较差异均无统计学意义(P>0.05)；行符合方案分析分别为88.0%、96.2%、89.3%、96.0%，各组比较差异均无统计学意义(P>0.05)。结论复合磷酸酯酶肠溶片治疗肝病患者腹胀的效果好，疗效与复方消化酶相当，且无明显的不良反应。

关键词：复合磷酸酯酶肠溶片；腹胀；复方消化酶

作者简介：牛庆慧,女，主治医师,研究方向：肝病的临床诊治，E-mail:niuqinghui@yeah.net

通讯作者：边城，男，博士研究生，教授，硕士生导师，研究方向：病毒性肝炎、肝纤维化及脂肪肝的防治，Tel:0532-82911203,E-mail:jinbeibei@126.com

中图分类号：R969.4文献标识码：A

Analysis of curative effect in the treatment of abdominal distension in patients with liver diseases

by using Phosphoesterases Complex Enteric Coated Tablets

NIUQing-hui1,BIANCheng1,JIANGYue-ping2,YANGYu-ling1，LIUPei1,ZHANGFeng-juan1,ZHANGHan1

(1.DepartmentofInfection,TheAffiliatedHospitalofQingdaoUniversity,Qingdao266555,China;

2.DepartmentofGastroenterology，TheAffiliatedHospitalofQingdaoUniversity,Qingdao266003，China)

Abstract：ObjectiveTo evaluate the effect of Phosphoesterases Complex Enteric Coated Tablets in abdominal distension patients with viral hepatitis type B,and was compared with the compound digestive enzyme.Methods107 cases of chronic hepatitis B as the main symptoms of the patients with abdominal distention,were divided into Phosphoesterases Complex Enteric Coated Tablets for 14 days group (group 1,25 cases)，Phosphoesterases Complex Enteric Coated Tablets for 28 days group (group 2,27 cases),Compound Digestive Enzymes for 14 days group (group 3,28 cases),Compound Digestive Enzymes for 28 days group (group 4,27 cases).After treatment,the remission rate and adverse reaction were observed.intent-to-treat analysis and per-protocol analysis were adopted with χ2 test.ResultsAfter treatment,the abdominal distension of 4 groups was released，and the results of intent-to-treat analysis were 88.0%，92.6%，89.3%，96.3%,respectively.There had no statistical difference (P>0.05);The results of per-protocol analysis were 88.0%，96.2%，89.3%，96.0%,respectively,and there had no statistical difference(P>0.05).ConclusionThe curative effect of Phosphoesterases Complex Enteric Coated Tablets in the treatment of abdominal distension in patients with liver disease was good as well as Compound Digestive Enzyme,and had no obvious adverse reaction.

Key words:Phosphoesterases Complex Enteric Coated Tablets;Abdominal distension;Compound digestive enzyme

目前世界上大约有3.5亿人患有慢性乙型病毒性肝炎[1]。肝炎病人往往会出现腹胀症状，其原因是多方面的：肝炎时，肝细胞分泌胆汁的功能失常，胰腺分泌胰液的功能也受到影响，而胆汁和胰液都是重要的消化液，二者总量的下降必然影响到胃肠的消化，尤其蛋白质和脂肪的吸收；肝炎时，……