融合性网状乳头瘤病25例临床及治疗分析

江妍南平市疾病预防控制中心，福建南平　353000

融合性网状乳头瘤病25例临床及治疗分析

江妍
南平市疾病预防控制中心，福建南平353000

目的 探讨融合性网状乳头瘤病的临床表现及有效治疗。方法 方便选取并回顾性分析2010年3月—2015年3月该院收治的25例融合性网状乳头瘤患者的临床表现、病理特点及有效治疗。结果 融合性网状乳头瘤病主要的临床表现为躯干部出现灰褐色扁平疣状斑丘疹，常相互融合呈网状，表面有轻度角化，真菌镜检阴性。病理特征：表皮角化过度，棘层肥厚，乳头瘤样增生。真皮浅层少量淋巴细胞浸润。治疗：经过8周口服米诺环素的治疗，25例患者中有9例患者痊愈，6例基本治愈，6例显效，2例有效，2例无效，所有患者在治疗过程及随访时间里均未发生明显不良反应。结论 米诺环素对融合性网状乳头瘤病有较好的临床疗效，且无明显不良反应，值得在临床上推广。

融合性网状乳头瘤病；临床及治疗分析

［Abstract］Objective To explore Clinical effect and Security of minocycline on confluent and reticulate papillomatosise. MethodsFrom March 2010 to March 2015，25 confluent and reticulate papillomatosise patients were selected，treatment with minocycline orally，for 8 weeks，and to observe the clinical effect and safety.Results Fusion of the clinical manifestation of reticulate papillomatosis is that the patients’body has dense papules，color is brown，some patients with patchy papules with reticulate surface intersection，slight keratinization，slightly higher than the skin in the affected area，edge light color，it has no obvious desquamation.After 7 weeks of treatment，9 cases were cured，6 cases were basically cured，6 cases were cured，2 cases is effective in the treatment of，2 case was ineffective；patients were followed up for 6 months，during this period，three patients had recurrence，again using the minocycline hydrochloride is still valid，and were cured.All patients during treatment and followed up for 6 months showed no adverse reactions.Conclusion Minocycline on fusion of mesh nipple papilloma has better clinical curative effect，and has no adverse reactions，it is worth popularizing in clinic.

［Key words］Minocycline confluent and reticulate papillomatosis；Clinical efficacy

融合性网状乳头瘤病（CRP）是一种临床上少见且病因不明的皮肤病，主要症状为患者的躯干处出现灰褐色的扁平丘疹或斑丘疹，且常互相融合呈斑片状或网状，主要患处在胸背部，常易被误诊为其它类皮肤病，如花斑癣和色素性痒疹等［1］，治疗方法一般选用药物治疗，有研究报道采用米诺环素治疗该种疾病有较好的效果［2］，该研究方便选取2010年3月—2015年3月该院收治的融合性网状乳头瘤患者25例，采用口服米诺环素的方法治疗，效果较好，现报道如下。……