肝动脉栓塞联合T细胞克隆技术治疗结肠癌肝转移临床研究

陈文生　冯　燕　郝忠臣　侯传伟　王振奇　赵　雷　孙庆春吉化集团公司总医院介入科，吉林吉林　132022

肝动脉栓塞联合T细胞克隆技术治疗结肠癌肝转移临床研究

陈文生冯燕郝忠臣侯传伟王振奇赵雷孙庆春
吉化集团公司总医院介入科，吉林吉林132022

目的探讨肝动脉栓塞（TACE）联合T细胞克隆技术治疗结肠癌肝转移的临床疗效。方法选择2010年1月～2014年12月结肠癌肝转移患者64例的临床资料进行回顾性分析，33例患者给予肝动脉栓塞治疗为对照组，31例患者在此基础上给予T细胞克隆技术治疗为研究组。比较两组的临床疗效及治疗后外周血T细胞亚群。结果研究组总有效率显著高于对照组，差异有统计学意义（P＜0.05）。研究组治疗后总T细胞亚群、CD4+T细胞亚群、CD8+T细胞亚群显著高于对照组，差异有高度统计学意义（P＜0.01）。结论肝动脉栓塞联合T细胞克隆技术治疗结肠癌肝转移能够改善患者的预后。

肝动脉栓塞；T细胞克隆技术；结肠癌；肝转移

［Abstract］Objective To discuss clinicalefficacy of hepatic artery embolization combined with T cell cloning technology in the treatment of livermetastasis from colon cancer.M ethods Clinical data of 64 cases with liver metastasis from colon cancer from Jan 2010 to Dec 2014 were respectively analyzed.33 cases of control group were treated with hepatic arterial embolization，and 31 cases of study group were treated with hepatic artery embolization combined with T cell cloning technology.Clinical efficacy and peripheral blood T cell subsets after treatment of two groups were compared. Results Total effective rate of study group was higher than control group（P＜0.05）.After treatment，the total T cell subsets CD4+T cell subsets and CD8+T cell subsets in study group were higher than control group（P＜0.01）.Conclusion Hepatic artery embolization combined with T cell cloning technology in the treatment of liver metastasis from colon cancer can improve the prognosis.

［Key words］Hepatic artery embolization；T cell cloning technology；Colon cancer；Livermetastasis

结肠癌是临床常见的恶性肿瘤，一旦发生肝转移，具有较高的死亡率，是导致治疗失败的主要原因。结肠癌无肝脏转移的患者5年的生存率较有肝脏转移的患者要高。提高发生肝脏转移结肠癌患者的生存率是治疗的关键。肝动脉介入治疗是治疗结肠癌肝脏转移的主要方法。T细胞克隆技术，能够促进增殖，提高杀瘤活性，并且杀瘤谱广［1，2］。自体细胞免疫治疗成为治疗晚期结肠癌的重要方法，并且具有毒性低的优点［3，4］。本文采用肝动脉栓塞联合T细胞克隆技术治疗结肠癌肝转移取得了较好的效果。……