注射用鼠神经生长因子对急性脑梗死患者神经功能康复的影响

陈奋伟

[摘要] 目的 探讨注射用鼠神经生长因子对急性脑梗死患者神经功能康复的影响。 方法 选择我院2012年12月～2016年1月收治的200例脑梗死患者作为研究对象，按照随机数字表法將其分为观察组与对照组，每组100例。对照组仅给予常规基础治疗，观察组在此基础上加用鼠神经生长因子治疗，观察组加用外源性鼠神经生长因子20μg每天1次肌内注射，共4周。使用美国国立卫生研究所脑卒中量表（NIHSS）评价神经功能恢复情况，记录两组患者临床治疗效果。 结果 观察组患者治疗2周后及4周后NIHSS量表评分降低幅度均显著低于治疗前和对照组治疗后，差异有统计学意义（P<0.05）；观察组总有效率为91.0%，明显高于对照组的73.0%，差异有统计学意义（P<0.05）。 结论 注射用鼠神经生长因子对急性脑梗死患者神经功能康复有明显改善作用，提高临床疗效，值得推广。

[关键词] 鼠神经生长因子；脑梗死；神经功能；疗效

[中图分类号] R743.3 [文献标识码] A [文章编号] 2095-0616（2017）05-65-03

[Abstract] Objective To investigate the effect of nerve growth factor （NGF） on neurological rehabilitation in patients with acute cerebral infarction. Methods 200 cases of cerebral infarction cured in our hospital from December 2012 to January 2016 were selected and divided into observation group and control group according to the random number table method，100 cases in each group.Patients in control group were treated woth only routine basic therapy.Patients in observation group were treated with nerve growth factor on the basis of control group.The rats in the observation group were treated with intramuscular injection of exogenous rat nerve growth factor 30μg once a day for 4 weeks.Neurological functional recovery was assessed using the National Institutes of Health Stroke Scale （NIHSS）.Clinical outcomes were recorded for both groups. Results The NIHSS scale scores of the patients in the observation group after 2 weeks and 4 weeks were significantly lower than those before treatment and control （P<0.05）.The total effective rate of the observation group was 91.0%，which was significantly higher than that of the control group with 73.0% （P<0.05）. Conclusion In the clinical treatment of patients with cerebral infarction，the combination of routine treatment and nerve growth factor can improve the neurological deficit symptoms，improve the effectiveness of treatment，and shorten the recovery rate of neurological function in patients with cerebral infarction.

[Key words] Nerve growth factor；Cerebral infarction；Neurological function；Efficacy

急性脑梗死是中老年人群高发的疾病之一，并且随着国内国民经济的不断发展，国民的生活水平也得到了提高，脑梗死的发病率呈现上升趋势，因脑梗塞产生的死亡率也逐渐增高，而患者年龄逐渐趋于年轻化[1-2]。脑梗死最为常见的后遗症是偏瘫，偏瘫又被称为半身不遂，是人体半侧上下肢、面肌及舌肌下部的运动功能障碍，对其生活质量可能造成严重影响。鼠神经生长因子广泛存在于成熟大脑各脑区，通过调节钙离子平衡、拮抗兴奋性氨基酸的神经毒性及对抗自由基的作用发挥其对神经元的保护功能[3-5]。我院采用注射用鼠神经生长因子治疗急性脑梗死，效果显著，现报道如下。

1 资料与方法

1.1 一般资料