根治性前列腺癌病理分期及pT2病理亚分期的意义

齐春海

[摘要] 目的 研究探讨根治性前列腺癌病理分期及pT2病理亚分期的意义，为前列腺癌的临床治疗提供更多的客观依据。方法 选取2013年1月～2015年1月于我院诊治的50例根治性前列腺癌患者，对入选研究对象的病理标本进行形态学观察，依据2002/2010年TNM分期系统对病理标本进行病理分期，同时对pT2病理亚分期的患者进行电话跟踪随访，然后对结果进行数据统计学分析。 结果 在术后病理分期中，pT2期有25例，pT3a期有15例，pT3b期有10例；其中在pT2期患者中，pT2a期占3例（12%），pT2b期占0例（0），pT2c期占22例（88%）。在对pT2病理亚分期的患者进行电话跟踪随访后，pT2a期与pT2c期患者均存活，两组之间的存活率比较差异无统计学意义（P>0.05）。 结论 根治性前列腺癌术后的病理分期能更加直接、真实的反映前列腺癌的状态，对患者的预后评估和判断更有价值和意义；同时pT2病理亚分期的分期依据并不十分完善，尚需要进一步优化改善。

[关键词] 根治性前列腺癌；病理分期；pT2病理亚分期；临床意义

[中图分类号] R737.2 [文献标识码] A [文章编号] 2095-0616（2017）05-194-03

[Abstract] Objective To study and explore the significance of pathological staging and pathological staging of pT2 in patients with prostate cancer，and to provide more objective basis for clinical treatment of prostate cancer. Methods 50 cases of radical prostatectomy cured in our hospital from January 2013 to January 2015 were selected.Morphological observation were carried on the pathological specimens of selected subjects.Pathological staging was performed according to the TNM staging system of 2002/2010.At the same time，the patients with pathological staging of pT2 were followed up by telephone.Statistical analysis of the results was carried on. Results In the postoperative pathological staging，there were 25 cases in pT2 stage，15 cases in pT3a stage，and 10 cases in pT3b stage.Among the patients with stage，3 cases of pT2a （12%），0 cases of pT2b （0），22 cases of pT2c （88%）.The patients were followed up by telephone for pathological staging of pT2，all the patients with stage pT2a and stage pT2c survived.There was no significant difference in survival rate between the two groups，and the difference was not statistically significant （P>0.05）. Conclusion Pathological staging after radical prostatectomy can more directly and truly reflect the shape of prostate cancer.It is more valuable and meaningful to evaluate and judge the prognosis of patients.At the same time，the pathological staging of pT2 is not perfect，and it needs further optimization and improvement.

[Key words] Radical prostate cancer；Pathological staging；PT2 pathological staging；Clinical significance

前列腺癌是發生于前列腺上的一种上皮性恶性肿瘤性疾病，本病在男性恶性肿瘤中的发病率较高，且随着年龄的增长其发病率亦呈现出上升的趋势，尤其是近年来随着人口老龄化的加剧，本病的发病率明显上升[1-2]。前列腺癌早期患者可无症状，但随着肿瘤的进一步发展，患者的症状逐渐出现，比如进行性排尿困难、会阴部疼痛等[3]。当前，临床上对于本病的治疗主要包括根治性前列腺切除、根治性放射治疗、药物治疗等等，而临床上具体治疗方法的选择主要是依据患者自身的身体状况以及患者肿瘤的分级、分期[4]。其……