葛敏


[摘要] 目的 探讨异搏定和胺碘酮治疗阵发性室上性心动过速的临床效果。方法 方便选取2015年1月—2016年1月该院收治的阵发性上性心动过速患儿88例,按照随机数字表法,分为对照组(n=44)与观察组(n=44)。对照组采用异搏定进行治疗,观察组采用胺碘酮进行治疗,比较两组治疗效果及不良反应发生率。 结果 经过相应药物治疗后,对照组治疗总有效率为88.64%,观察组治疗总有效率为93.18%,两组差异无统计学意义(P>0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。 结论 异搏定和胺碘酮治疗阵发性室上性心动过速均具有显著治疗效果,但相较异搏定,胺碘酮的不良反应更少,因此具有更为显著的临床应用价值。
[关键词] 异搏定;胺碘酮;阵发性室上性心动过速
[中图分类号] R541 [文献标识码] A [文章编号] 1674-0742(2017)05(c)-0151-03
[Abstract] Objective To study the clinical effect of verapamil and amiodarone in treatment of paroxysmal supraventricular tachycardia. Methods Convenient selection 88 cases of children with paroxysmal supraventricular tachycardia admitted and treated in our hospital from January 2015 to January 2016 were selected and randomly divided into two groups with 44 cases in each, the control group were treated with verapamil, while the observation group were treated with amiodarone, and the treatment effect and incidence rate of adverse reactions were compared between the two groups. Results After the treatment, the difference in the total effective rate between the control group and the observation group was not statistically significant(88.64% vs 93.18%)(P>0.05), and the incidence rate of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant(P<0.05). Conclusion The effect of verapamil and amiodarone in treatment of paroxysmal supraventricular tachycardia is obvious, but the adverse reactions of amiodarone are fewer than those of verapamil, therefore, it is worth clinical application.
[Key words] Verapamil; Amiodarone; Paroxysmal supraventricular tachycardia
陣发性室上性心动过速(PSVT)起源于心房或是房室交界处,大部分由折返导致[1]。PSVT为最常见的小儿心律失常,约占小儿心律失常的90%。在儿科患者中,男性PSVT患儿的数量多于女性,PSVT患儿可能存在器质性心脏病,也可能不存在器质性心脏病,当患儿发生PSVT时,其血压会出现明显的降低,心搏量会明显减少,心功能可能出现恶化等[2]。异搏定以及胺碘酮为转复药物,临床应用率均较高[3]。该研究方便选取2015年1月—2016年1月该院收治的阵发性上性心动过速患儿88例,探讨异搏定和胺碘酮治疗阵发性室上性心动过速的临床效果,现报道如下。
1 资料与方法
1.1 一般资料
该研究方便选取的研究对象为2015年1月—2016年1月该院收治的符合WHO诊断标准的阵发性上性心动过速患儿88例,按照随机数字表法,分为对照组(n=44)与观察组(n=44)。对照组男26例,女18例,年龄2~13岁,平均(8.6±1.9)岁,其中先天性心脏病12例,病毒性心肌炎18例,感染性肺炎9例,缺氧缺血性脑病5例,PSVT发作时的心率为149~209次/min,平均(168±13)次/min;观……