D—二聚体检测对糖尿病的临床意义分析与研究

陈智阳+黄江山+陈芒好

[摘要] 目的 探讨D-二聚体检测对于糖尿病诊断的临床意义。方法 选取选取该院收治的糖尿病患者80例，根据是否合并并发症将其分为两组，同时选择同期参与体检的健康志愿者50名作为对照，比较3组D-二聚体、纤维蛋白原以及糖化血红蛋白。 结果 糖尿病合并并发症组患者的D-D、Fib以及HbAlc都显著高于糖尿病不合并并发症组患者、健康志愿者（P<0.05）。糖尿病不合并并发症组患者与健康志愿者在D-D、Fib的比较上差异无统计学意义（P>0.05），而HbA1c的比较则有糖尿病不合并并发症组患者显著高于健康志愿者的情况（P<0.05）。结论 通过D-二聚体的检测可以为糖尿病并发症的早期临床诊断提供依据，为病情的控制提供指导，值得临床推广应用。

[关键词] D-二聚体；糖尿病；临床意义

[中图分类号] R587 [文献标识码] A [文章编号] 1672-4062（2017）04（a）-0073-03

[Abstract] Objective To study the clinical significance of D-dipolymer detection in the diabetes. Methods 80 cases of diabetes patients admitted and treated in our hospital were selected and divided into two groups according to the complications， and 50 cases of healthy physical examination volunteers at the same period were selected as the control group， and the D-dipolymer， fibrinogen and glycosylated hemoglobin were compared between the three groups. Results The D-D， Fib and HbAlc in the patients with diabetes with complications were obviously higher than those in patients with diabetes without complications and healthy volunteers（P<0.05）， and the differences in the D-D and Fib between the patients with diabetes without complications and healthy volunteers（P>0.05）， and the HbAlc in patients with diabetes without complications was higher than that of healthy volunteers（P<0.05）. Conclusion The D-dipolymer detection can provide basis for the early clinical diagnosis of diabetic complications and provide guidance for the control of diseases， which is worth clinical promotion and application.

[Key words] D-dipolymer； Diabetes； Clinical significance

糖尿病是世界性公共健康問题，随着人们生活、饮食习惯的改变，糖尿病的发病率不断升高。糖尿病不仅影响患者的身心健康和日常生活，其慢性并发症也成为导致患者残疾、死亡的重要原因。常见的糖尿病并发疾病是血管病变，如糖尿病肾病、糖尿病视网膜病变、心血管疾病等，对早期血管病变的及时发现和积极干预是控制病情，延缓病情发展的重要环节。该文选取该院收治的糖尿病患者80例作为研究对象，旨在分析D-二聚体对于糖尿病及其相关并发症诊断的临床意义，现报道如下。

1 资料与方法

1.1 一般资料

选取该院收治的糖尿病患者80例作为研究对象，患者均符合美国糖尿病协会（ADA）制定的诊断标准，且经检查，患者均不合并原发性心脑血管疾病、肝肾功能障碍以及其他内分泌系统疾病。按照糖尿病患者是否合并并发症将其分为两组，合并并发症组患者36例，不合并并发症组患者44例。……